TY - JOUR
T1 - Out of the frying pan and into the fire
T2 - Damage-Associated molecular patterns and cardiovascular toxicity following cancer therapy
AU - Klee, Nicole S.
AU - McCarthy, Cameron G.
AU - Martinez-Quinones, Patricia
AU - Webb, R. Clinton
N1 - Funding Information:
This work was supported by the National Institutes of Health (grant number HL-134604, Program Project Grant 2017-22).
Publisher Copyright:
© The Author(s), 2017.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Cardio-oncology is a new and rapidly expanding field that merges cancer and cardiovascular disease. Cardiovascular disease is an omnipresent side effect of cancer therapy; in fact, it is the second leading cause of death in cancer survivors after recurrent cancer. It has been well documented that many cancer chemotherapeutic agents cause cardiovascular toxicity. Nonetheless, the underlying cause of cancer therapy-induced cardiovascular toxicity is largely unknown. In this review, we discuss the potential role of damage-Associated molecular patterns (DAMPs) as an underlying contributor to cancer therapy-induced cardiovascular toxicity. With an increasing number of cancer patients, as well as extended life expectancy, understanding the mechanisms underlying cancer therapy-induced cardiovascular disease is of the utmost importance to ensure that cancer is the only disease burden that cancer survivors have to endure.
AB - Cardio-oncology is a new and rapidly expanding field that merges cancer and cardiovascular disease. Cardiovascular disease is an omnipresent side effect of cancer therapy; in fact, it is the second leading cause of death in cancer survivors after recurrent cancer. It has been well documented that many cancer chemotherapeutic agents cause cardiovascular toxicity. Nonetheless, the underlying cause of cancer therapy-induced cardiovascular toxicity is largely unknown. In this review, we discuss the potential role of damage-Associated molecular patterns (DAMPs) as an underlying contributor to cancer therapy-induced cardiovascular toxicity. With an increasing number of cancer patients, as well as extended life expectancy, understanding the mechanisms underlying cancer therapy-induced cardiovascular disease is of the utmost importance to ensure that cancer is the only disease burden that cancer survivors have to endure.
KW - cancer therapy
KW - cardio-oncology
KW - cardiotoxicity
KW - cardiovascular disease
KW - damage-Associated molecular patterns
KW - inflammation
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U2 - 10.1177/1753944717729141
DO - 10.1177/1753944717729141
M3 - Review article
C2 - 28911261
AN - SCOPUS:85031324847
SN - 1753-9447
VL - 11
SP - 297
EP - 317
JO - Therapeutic Advances in Cardiovascular Disease
JF - Therapeutic Advances in Cardiovascular Disease
IS - 11
ER -