Abstract
We present, to our knowledge, the first published series of corpus callosotomy (CC) in adults with medically intractable symptomatic generalized epilepsy (SGE). Fifteen adults were followed for the outcome measures of seizure and antiepileptic drug (AED) burden and quality of life (QoL). Five (33%) patients reported >. 60%, one (7%) reported between 30 and 60%, and nine (60%) reported <. 30% reduction in the total number of seizures after CC. Seven (47%) patients reported >. 60%, three (20%) experienced between 30 and 60%, and five (33%) reported <. 30% atonic seizure reduction. Twelve patients had no change in AED burden. Nine (60%) patients had no change in QoL, while six (40%) reported some improvement. Corpus callosotomy should be considered as a safe option for adults with medically intractable SGE with demonstrated reduction in the frequency of atonic seizures, and some patients experience a meaningful improvement in quality of life.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-184 |
| Number of pages | 4 |
| Journal | Epilepsy and Behavior |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2013 |
| Externally published | Yes |
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Keywords
- All epilepsy/seizures
- Epilepsy surgery
- Generalized seizures
- Vagus nerve stimulation
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Behavioral Neuroscience
Cite this
Outcome of corpus callosotomy in adults. / Park, Michael S.; Nakagawa, Emily; Schoenberg, Mike R.; Benbadis, Selim R.; Vale, Fernando L.
In: Epilepsy and Behavior, Vol. 28, No. 2, 08.2013, p. 181-184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Outcome of corpus callosotomy in adults
AU - Park, Michael S.
AU - Nakagawa, Emily
AU - Schoenberg, Mike R.
AU - Benbadis, Selim R.
AU - Vale, Fernando L.
PY - 2013/8
Y1 - 2013/8
N2 - We present, to our knowledge, the first published series of corpus callosotomy (CC) in adults with medically intractable symptomatic generalized epilepsy (SGE). Fifteen adults were followed for the outcome measures of seizure and antiepileptic drug (AED) burden and quality of life (QoL). Five (33%) patients reported >. 60%, one (7%) reported between 30 and 60%, and nine (60%) reported <. 30% reduction in the total number of seizures after CC. Seven (47%) patients reported >. 60%, three (20%) experienced between 30 and 60%, and five (33%) reported <. 30% atonic seizure reduction. Twelve patients had no change in AED burden. Nine (60%) patients had no change in QoL, while six (40%) reported some improvement. Corpus callosotomy should be considered as a safe option for adults with medically intractable SGE with demonstrated reduction in the frequency of atonic seizures, and some patients experience a meaningful improvement in quality of life.
AB - We present, to our knowledge, the first published series of corpus callosotomy (CC) in adults with medically intractable symptomatic generalized epilepsy (SGE). Fifteen adults were followed for the outcome measures of seizure and antiepileptic drug (AED) burden and quality of life (QoL). Five (33%) patients reported >. 60%, one (7%) reported between 30 and 60%, and nine (60%) reported <. 30% reduction in the total number of seizures after CC. Seven (47%) patients reported >. 60%, three (20%) experienced between 30 and 60%, and five (33%) reported <. 30% atonic seizure reduction. Twelve patients had no change in AED burden. Nine (60%) patients had no change in QoL, while six (40%) reported some improvement. Corpus callosotomy should be considered as a safe option for adults with medically intractable SGE with demonstrated reduction in the frequency of atonic seizures, and some patients experience a meaningful improvement in quality of life.
KW - All epilepsy/seizures
KW - Epilepsy surgery
KW - Generalized seizures
KW - Vagus nerve stimulation
UR - http://www.scopus.com/inward/record.url?scp=84878990213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878990213&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2013.04.015
DO - 10.1016/j.yebeh.2013.04.015
M3 - Article
C2 - 23747503
AN - SCOPUS:84878990213
VL - 28
SP - 181
EP - 184
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
IS - 2
ER -