Outcome of corpus callosotomy in adults

Michael S. Park, Emily Nakagawa, Mike R. Schoenberg, Selim R. Benbadis, Fernando L. Vale

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


We present, to our knowledge, the first published series of corpus callosotomy (CC) in adults with medically intractable symptomatic generalized epilepsy (SGE). Fifteen adults were followed for the outcome measures of seizure and antiepileptic drug (AED) burden and quality of life (QoL). Five (33%) patients reported >. 60%, one (7%) reported between 30 and 60%, and nine (60%) reported <. 30% reduction in the total number of seizures after CC. Seven (47%) patients reported >. 60%, three (20%) experienced between 30 and 60%, and five (33%) reported <. 30% atonic seizure reduction. Twelve patients had no change in AED burden. Nine (60%) patients had no change in QoL, while six (40%) reported some improvement. Corpus callosotomy should be considered as a safe option for adults with medically intractable SGE with demonstrated reduction in the frequency of atonic seizures, and some patients experience a meaningful improvement in quality of life.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalEpilepsy and Behavior
Issue number2
StatePublished - Aug 2013
Externally publishedYes


  • All epilepsy/seizures
  • Epilepsy surgery
  • Generalized seizures
  • Vagus nerve stimulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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