Abstract
BACKGROUND: Patients with therapy-related acute promyelocytic leukemia (t-APL) have been commonly exposed to topoisomerase inhibitors and may potentially benefit from induction regimens omitting anthracyclines. METHODS: Retrospective analysis of the outcomes of 29 patients with t-APL who were either treated with arsenic trioxide (ATO) and all-trans-retinoic acid (ATRA) or with standard ATRA plus anthracycline-based chemotherapy was performed. RESULTS: Prior therapy included chemotherapy alone, radiation alone, or a combination of the 2 in 19%, 33%, and 47% of patients, respectively. The combination of ATO and ATRA (n = 19) for induction resulted in a similar remission rate compared with ATRA plus chemotherapy (n = 10) (89% vs 70%; P =.35). The median overall survival for the patients treated with ATRA plus ATO was not reached compared with that for patients treated with ATRA plus chemotherapy (161 weeks; P =.79). CONCLUSIONS: In this cohort of t-APL patients, outcomes with ATO and ATRA appeared to be comparable to anthracycline-containing induction regimens. This combination may be preferable in t-APL patients to avoid any risk of anthracycline-induced toxicities. Cancer 2011.
Original language | English (US) |
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Pages (from-to) | 110-115 |
Number of pages | 6 |
Journal | Cancer |
Volume | 117 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2011 |
Externally published | Yes |
Keywords
- all-trans-retinoic acid
- arsenic trioxide
- outcome
- therapy-related acute promyelocytic leukemia
ASJC Scopus subject areas
- Oncology
- Cancer Research