Ovarian steroids and modulation of morphine-induced analgesia and catalepsy in female rats

Papri Banerjee, Tapan K. Chatterjee, Jagat J. Ghosh

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Abstract

The influence of ovarian steroids on modulation of antinociceptive and cataleptic responses to morphine in female rats was evaluated. The sensitivity of the animals to morphine varied at different stages of the estrous cycle. The responses of postpartum and ovariectomized rats to morphine was attenuated. The test doses of estradiol-17β or progesterone, either alone or in combination, did not alter this attenuated morphine sensitivity. Testosterone, however, sensitized post-partum as well as ovariectomized rats to morphine. Unlike progesterone, 17-α-hydroxy progesterone antagonized testosterone. Collectively these data implicate ovarian testosterone as a physiological modulator of actions of morphine in female rats.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalEuropean Journal of Pharmacology
Volume96
Issue number3-4
DOIs
Publication statusPublished - Dec 23 1983

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Keywords

  • Estrous cycle
  • Morphine
  • Ovarian steroids
  • Post-partum condition

ASJC Scopus subject areas

  • Pharmacology

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