Ovarian steroids and modulation of morphine-induced analgesia and catalepsy in female rats

Papri Banerjee; Tapan K. Chatterjee; Jagat J. Ghosh

doi:10.1016/0014-2999(83)90319-9

Ovarian steroids and modulation of morphine-induced analgesia and catalepsy in female rats

Papri Banerjee, Tapan K. Chatterjee, Jagat J. Ghosh

Medicine

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72 Scopus citations

Abstract

The influence of ovarian steroids on modulation of antinociceptive and cataleptic responses to morphine in female rats was evaluated. The sensitivity of the animals to morphine varied at different stages of the estrous cycle. The responses of postpartum and ovariectomized rats to morphine was attenuated. The test doses of estradiol-17β or progesterone, either alone or in combination, did not alter this attenuated morphine sensitivity. Testosterone, however, sensitized post-partum as well as ovariectomized rats to morphine. Unlike progesterone, 17-α-hydroxy progesterone antagonized testosterone. Collectively these data implicate ovarian testosterone as a physiological modulator of actions of morphine in female rats.

Original language	English (US)
Pages (from-to)	291-294
Number of pages	4
Journal	European Journal of Pharmacology
Volume	96
Issue number	3-4
DOIs	https://doi.org/10.1016/0014-2999(83)90319-9
State	Published - Dec 23 1983

Keywords

Estrous cycle
Morphine
Ovarian steroids
Post-partum condition

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(83)90319-9

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abstract = "The influence of ovarian steroids on modulation of antinociceptive and cataleptic responses to morphine in female rats was evaluated. The sensitivity of the animals to morphine varied at different stages of the estrous cycle. The responses of postpartum and ovariectomized rats to morphine was attenuated. The test doses of estradiol-17β or progesterone, either alone or in combination, did not alter this attenuated morphine sensitivity. Testosterone, however, sensitized post-partum as well as ovariectomized rats to morphine. Unlike progesterone, 17-α-hydroxy progesterone antagonized testosterone. Collectively these data implicate ovarian testosterone as a physiological modulator of actions of morphine in female rats.",

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AU - Ghosh, Jagat J.

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AB - The influence of ovarian steroids on modulation of antinociceptive and cataleptic responses to morphine in female rats was evaluated. The sensitivity of the animals to morphine varied at different stages of the estrous cycle. The responses of postpartum and ovariectomized rats to morphine was attenuated. The test doses of estradiol-17β or progesterone, either alone or in combination, did not alter this attenuated morphine sensitivity. Testosterone, however, sensitized post-partum as well as ovariectomized rats to morphine. Unlike progesterone, 17-α-hydroxy progesterone antagonized testosterone. Collectively these data implicate ovarian testosterone as a physiological modulator of actions of morphine in female rats.

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KW - Ovarian steroids

KW - Post-partum condition

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Ovarian steroids and modulation of morphine-induced analgesia and catalepsy in female rats

Abstract

Keywords

ASJC Scopus subject areas

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