Abstract
Objective: To evaluate the effect on ovulation of a 10-day course of dexamethasone (DEX) initiated concurrently with a 5-day course of clomiphene citrate (CC) in CC-resistant patients with normal DHEAS levels. Design: Retrospective review. Settings: Patients from the clinical practice of the authors at the Medical College of Georgia, Augusta, Georgia. Patients: Thirteen oligomenorrheic women with normal DHEAS levels who failed to ovulate on a graduated regimen of CC up to a dose of 150 mg for 5 days. Interventions: Ten-day course of DEX initiated concurrently with a 5-day course of CC; ovulation and pregnancy outcomes recorded. Main Outcome Measure: Pregnancy. Results: Eleven of 13 women had evidence of ovulation. Five clinical pregnancies were achieved. Conclusion: These initial data support improvements in follicular development with an overlapping follicular phase regimen of CC and DEX in patients with normal DHEAS levels and a previous poor response.
Original language | English (US) |
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Pages (from-to) | 484-486 |
Number of pages | 3 |
Journal | Fertility and sterility |
Volume | 66 |
Issue number | 3 |
DOIs | |
State | Published - 1996 |
Keywords
- Clomiphene citrate
- DHEAS
- anovulation
- dexamethasone
- ovulation induction
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology