Oxidative stress and cardiovascular disease: Antioxidants and unresolved issues

Kamakshi Sachidanandam, Susan C. Fagan, Adviye Ergul

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

Experimental and clinical studies suggest that oxidative stress contributes to the development and progression of cardiovascular disease. However, clinical trials with classic vitamin antioxidants failed to demonstrate any benefit in cardiovascular outcomes. Recent advances in our understanding of mechanisms involved in free radical generation reinstate that a more comprehensive approach targeting the prevention of reactive oxygen species (ROS) formation early in the disease process may prove beneficial. Experimental studies and reviews in oxidative stress were selected to provide a better understanding of the roles of the reactive species in the initiation and progression of cardiovascular disease (CVD). Clinical studies that evaluated the efficacy of several classes of antioxidants in CVD were included in the second part of this review to discuss future therapeutic guidelines based on currently available evidence. In conclusion, before a potential role for antioxidants in the treatment of CVD is eliminated, more carefully designed studies with classic as well as new antioxidants in well-defined patient populations are warranted to provide a definitive answer.

Original languageEnglish (US)
Pages (from-to)115-132
Number of pages18
JournalCardiovascular Drug Reviews
Volume23
Issue number2
StatePublished - Sep 19 2005

Fingerprint

Oxidative Stress
Cardiovascular Diseases
Antioxidants
Vitamins
Free Radicals
Reactive Oxygen Species
Clinical Trials
Guidelines
Therapeutics
Population
Clinical Studies

Keywords

  • Antioxidant vitamins
  • Antioxidants
  • Cardiovascular disease
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Sachidanandam, K., Fagan, S. C., & Ergul, A. (2005). Oxidative stress and cardiovascular disease: Antioxidants and unresolved issues. Cardiovascular Drug Reviews, 23(2), 115-132.

Oxidative stress and cardiovascular disease : Antioxidants and unresolved issues. / Sachidanandam, Kamakshi; Fagan, Susan C.; Ergul, Adviye.

In: Cardiovascular Drug Reviews, Vol. 23, No. 2, 19.09.2005, p. 115-132.

Research output: Contribution to journalReview article

Sachidanandam, K, Fagan, SC & Ergul, A 2005, 'Oxidative stress and cardiovascular disease: Antioxidants and unresolved issues', Cardiovascular Drug Reviews, vol. 23, no. 2, pp. 115-132.
Sachidanandam, Kamakshi ; Fagan, Susan C. ; Ergul, Adviye. / Oxidative stress and cardiovascular disease : Antioxidants and unresolved issues. In: Cardiovascular Drug Reviews. 2005 ; Vol. 23, No. 2. pp. 115-132.
@article{c07e0347f5d94951a54f94ccc1d815aa,
title = "Oxidative stress and cardiovascular disease: Antioxidants and unresolved issues",
abstract = "Experimental and clinical studies suggest that oxidative stress contributes to the development and progression of cardiovascular disease. However, clinical trials with classic vitamin antioxidants failed to demonstrate any benefit in cardiovascular outcomes. Recent advances in our understanding of mechanisms involved in free radical generation reinstate that a more comprehensive approach targeting the prevention of reactive oxygen species (ROS) formation early in the disease process may prove beneficial. Experimental studies and reviews in oxidative stress were selected to provide a better understanding of the roles of the reactive species in the initiation and progression of cardiovascular disease (CVD). Clinical studies that evaluated the efficacy of several classes of antioxidants in CVD were included in the second part of this review to discuss future therapeutic guidelines based on currently available evidence. In conclusion, before a potential role for antioxidants in the treatment of CVD is eliminated, more carefully designed studies with classic as well as new antioxidants in well-defined patient populations are warranted to provide a definitive answer.",
keywords = "Antioxidant vitamins, Antioxidants, Cardiovascular disease, Oxidative stress, Reactive oxygen species",
author = "Kamakshi Sachidanandam and Fagan, {Susan C.} and Adviye Ergul",
year = "2005",
month = "9",
day = "19",
language = "English (US)",
volume = "23",
pages = "115--132",
journal = "Cardiovascular Drug Reviews",
issn = "0897-5957",
publisher = "Neva Press, Inc.",
number = "2",

}

TY - JOUR

T1 - Oxidative stress and cardiovascular disease

T2 - Antioxidants and unresolved issues

AU - Sachidanandam, Kamakshi

AU - Fagan, Susan C.

AU - Ergul, Adviye

PY - 2005/9/19

Y1 - 2005/9/19

N2 - Experimental and clinical studies suggest that oxidative stress contributes to the development and progression of cardiovascular disease. However, clinical trials with classic vitamin antioxidants failed to demonstrate any benefit in cardiovascular outcomes. Recent advances in our understanding of mechanisms involved in free radical generation reinstate that a more comprehensive approach targeting the prevention of reactive oxygen species (ROS) formation early in the disease process may prove beneficial. Experimental studies and reviews in oxidative stress were selected to provide a better understanding of the roles of the reactive species in the initiation and progression of cardiovascular disease (CVD). Clinical studies that evaluated the efficacy of several classes of antioxidants in CVD were included in the second part of this review to discuss future therapeutic guidelines based on currently available evidence. In conclusion, before a potential role for antioxidants in the treatment of CVD is eliminated, more carefully designed studies with classic as well as new antioxidants in well-defined patient populations are warranted to provide a definitive answer.

AB - Experimental and clinical studies suggest that oxidative stress contributes to the development and progression of cardiovascular disease. However, clinical trials with classic vitamin antioxidants failed to demonstrate any benefit in cardiovascular outcomes. Recent advances in our understanding of mechanisms involved in free radical generation reinstate that a more comprehensive approach targeting the prevention of reactive oxygen species (ROS) formation early in the disease process may prove beneficial. Experimental studies and reviews in oxidative stress were selected to provide a better understanding of the roles of the reactive species in the initiation and progression of cardiovascular disease (CVD). Clinical studies that evaluated the efficacy of several classes of antioxidants in CVD were included in the second part of this review to discuss future therapeutic guidelines based on currently available evidence. In conclusion, before a potential role for antioxidants in the treatment of CVD is eliminated, more carefully designed studies with classic as well as new antioxidants in well-defined patient populations are warranted to provide a definitive answer.

KW - Antioxidant vitamins

KW - Antioxidants

KW - Cardiovascular disease

KW - Oxidative stress

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=24644461022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644461022&partnerID=8YFLogxK

M3 - Review article

C2 - 16007229

AN - SCOPUS:24644461022

VL - 23

SP - 115

EP - 132

JO - Cardiovascular Drug Reviews

JF - Cardiovascular Drug Reviews

SN - 0897-5957

IS - 2

ER -