Abstract
Experimental and clinical studies suggest that oxidative stress contributes to the development and progression of cardiovascular disease. However, clinical trials with classic vitamin antioxidants failed to demonstrate any benefit in cardiovascular outcomes. Recent advances in our understanding of mechanisms involved in free radical generation reinstate that a more comprehensive approach targeting the prevention of reactive oxygen species (ROS) formation early in the disease process may prove beneficial. Experimental studies and reviews in oxidative stress were selected to provide a better understanding of the roles of the reactive species in the initiation and progression of cardiovascular disease (CVD). Clinical studies that evaluated the efficacy of several classes of antioxidants in CVD were included in the second part of this review to discuss future therapeutic guidelines based on currently available evidence. In conclusion, before a potential role for antioxidants in the treatment of CVD is eliminated, more carefully designed studies with classic as well as new antioxidants in well-defined patient populations are warranted to provide a definitive answer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 115-132 |
| Number of pages | 18 |
| Journal | Cardiovascular Drug Reviews |
| Volume | 23 |
| Issue number | 2 |
| State | Published - Sep 19 2005 |
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Keywords
- Antioxidant vitamins
- Antioxidants
- Cardiovascular disease
- Oxidative stress
- Reactive oxygen species
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine
Cite this
Oxidative stress and cardiovascular disease : Antioxidants and unresolved issues. / Sachidanandam, Kamakshi; Fagan, Susan C.; Ergul, Adviye.
In: Cardiovascular Drug Reviews, Vol. 23, No. 2, 19.09.2005, p. 115-132.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Oxidative stress and cardiovascular disease
T2 - Antioxidants and unresolved issues
AU - Sachidanandam, Kamakshi
AU - Fagan, Susan C.
AU - Ergul, Adviye
PY - 2005/9/19
Y1 - 2005/9/19
N2 - Experimental and clinical studies suggest that oxidative stress contributes to the development and progression of cardiovascular disease. However, clinical trials with classic vitamin antioxidants failed to demonstrate any benefit in cardiovascular outcomes. Recent advances in our understanding of mechanisms involved in free radical generation reinstate that a more comprehensive approach targeting the prevention of reactive oxygen species (ROS) formation early in the disease process may prove beneficial. Experimental studies and reviews in oxidative stress were selected to provide a better understanding of the roles of the reactive species in the initiation and progression of cardiovascular disease (CVD). Clinical studies that evaluated the efficacy of several classes of antioxidants in CVD were included in the second part of this review to discuss future therapeutic guidelines based on currently available evidence. In conclusion, before a potential role for antioxidants in the treatment of CVD is eliminated, more carefully designed studies with classic as well as new antioxidants in well-defined patient populations are warranted to provide a definitive answer.
AB - Experimental and clinical studies suggest that oxidative stress contributes to the development and progression of cardiovascular disease. However, clinical trials with classic vitamin antioxidants failed to demonstrate any benefit in cardiovascular outcomes. Recent advances in our understanding of mechanisms involved in free radical generation reinstate that a more comprehensive approach targeting the prevention of reactive oxygen species (ROS) formation early in the disease process may prove beneficial. Experimental studies and reviews in oxidative stress were selected to provide a better understanding of the roles of the reactive species in the initiation and progression of cardiovascular disease (CVD). Clinical studies that evaluated the efficacy of several classes of antioxidants in CVD were included in the second part of this review to discuss future therapeutic guidelines based on currently available evidence. In conclusion, before a potential role for antioxidants in the treatment of CVD is eliminated, more carefully designed studies with classic as well as new antioxidants in well-defined patient populations are warranted to provide a definitive answer.
KW - Antioxidant vitamins
KW - Antioxidants
KW - Cardiovascular disease
KW - Oxidative stress
KW - Reactive oxygen species
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UR - http://www.scopus.com/inward/citedby.url?scp=24644461022&partnerID=8YFLogxK
M3 - Review article
C2 - 16007229
AN - SCOPUS:24644461022
VL - 23
SP - 115
EP - 132
JO - Cardiovascular Drug Reviews
JF - Cardiovascular Drug Reviews
SN - 0897-5957
IS - 2
ER -