Oxidative Stress and the Development of Endothelial Dysfunction in Congenital Heart Disease With Increased Pulmonary Blood Flow

Lessons From the Neonatal Lamb

Saurabh Aggarwal, Christine Gross, Jeffrey R. Fineman, Stephen Matthew Black

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.

Original languageEnglish (US)
Pages (from-to)238-246
Number of pages9
JournalTrends in Cardiovascular Medicine
Volume20
Issue number7
DOIs
StatePublished - Oct 1 2010

Fingerprint

Heart Diseases
Oxidative Stress
Lung
Pulmonary Hypertension
Vasodilation
Growth
Vascular Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Oxidative Stress and the Development of Endothelial Dysfunction in Congenital Heart Disease With Increased Pulmonary Blood Flow : Lessons From the Neonatal Lamb. / Aggarwal, Saurabh; Gross, Christine; Fineman, Jeffrey R.; Black, Stephen Matthew.

In: Trends in Cardiovascular Medicine, Vol. 20, No. 7, 01.10.2010, p. 238-246.

Research output: Contribution to journalReview article

Aggarwal, Saurabh ; Gross, Christine ; Fineman, Jeffrey R. ; Black, Stephen Matthew. / Oxidative Stress and the Development of Endothelial Dysfunction in Congenital Heart Disease With Increased Pulmonary Blood Flow : Lessons From the Neonatal Lamb. In: Trends in Cardiovascular Medicine. 2010 ; Vol. 20, No. 7. pp. 238-246.
@article{b5ce8dc72dc64376ab41e8b63ce00b05,
title = "Oxidative Stress and the Development of Endothelial Dysfunction in Congenital Heart Disease With Increased Pulmonary Blood Flow: Lessons From the Neonatal Lamb",
abstract = "Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.",
author = "Saurabh Aggarwal and Christine Gross and Fineman, {Jeffrey R.} and Black, {Stephen Matthew}",
year = "2010",
month = "10",
day = "1",
doi = "10.1016/j.tcm.2011.11.010",
language = "English (US)",
volume = "20",
pages = "238--246",
journal = "Trends in Cardiovascular Medicine",
issn = "1050-1738",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Oxidative Stress and the Development of Endothelial Dysfunction in Congenital Heart Disease With Increased Pulmonary Blood Flow

T2 - Lessons From the Neonatal Lamb

AU - Aggarwal, Saurabh

AU - Gross, Christine

AU - Fineman, Jeffrey R.

AU - Black, Stephen Matthew

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.

AB - Congenital heart diseases associated with increased pulmonary blood flow commonly leads to the development of pulmonary hypertension. However, most patients who undergo histological evaluation have advanced pulmonary hypertension, and therefore it has been difficult to investigate aberrations in signaling cascades that precede the development of overt vascular remodeling. This review discusses the role played by both oxidative and nitrosative stress in the lung and their impact on the signaling pathways that regulate vasodilation, vessel growth, and vascular remodeling in the neonatal lung exposed to increased pulmonary blood flow.

UR - http://www.scopus.com/inward/record.url?scp=84856328489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856328489&partnerID=8YFLogxK

U2 - 10.1016/j.tcm.2011.11.010

DO - 10.1016/j.tcm.2011.11.010

M3 - Review article

VL - 20

SP - 238

EP - 246

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

SN - 1050-1738

IS - 7

ER -