Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical pratice

Jeanette Schultz Johansen, Alex K. Harris, David J. Rychly, Adviye Ergul

Research output: Contribution to journalReview article

540 Citations (Scopus)

Abstract

Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. Despite overwhelming evidence on the damaging consequences of oxidative stress and its role in experimental diabetes, large scale clinical trials with classic antioxidants failed to demonstrate any benefit for diabetic patients. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes.

Original languageEnglish (US)
Article number5
JournalCardiovascular Diabetology
Volume4
DOIs
StatePublished - Apr 29 2005

Fingerprint

Free Radicals
Oxidative Stress
Antioxidants
Diabetes Complications
Membrane Lipids
Hyperglycemia
Nucleic Acids
Blood Vessels
Atherosclerosis
Clinical Trials
Morbidity
Mortality
Proteins
Therapeutics

Keywords

  • Antioxidants
  • Diabetes
  • Oxidative Stress

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Oxidative stress and the use of antioxidants in diabetes : Linking basic science to clinical pratice. / Johansen, Jeanette Schultz; Harris, Alex K.; Rychly, David J.; Ergul, Adviye.

In: Cardiovascular Diabetology, Vol. 4, 5, 29.04.2005.

Research output: Contribution to journalReview article

Johansen, Jeanette Schultz ; Harris, Alex K. ; Rychly, David J. ; Ergul, Adviye. / Oxidative stress and the use of antioxidants in diabetes : Linking basic science to clinical pratice. In: Cardiovascular Diabetology. 2005 ; Vol. 4.
@article{e506f61d879b4c25b6b30b5a7f0a1478,
title = "Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical pratice",
abstract = "Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. Despite overwhelming evidence on the damaging consequences of oxidative stress and its role in experimental diabetes, large scale clinical trials with classic antioxidants failed to demonstrate any benefit for diabetic patients. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes.",
keywords = "Antioxidants, Diabetes, Oxidative Stress",
author = "Johansen, {Jeanette Schultz} and Harris, {Alex K.} and Rychly, {David J.} and Adviye Ergul",
year = "2005",
month = "4",
day = "29",
doi = "10.1186/1475-2840-4-5",
language = "English (US)",
volume = "4",
journal = "Cardiovascular Diabetology",
issn = "1475-2840",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Oxidative stress and the use of antioxidants in diabetes

T2 - Linking basic science to clinical pratice

AU - Johansen, Jeanette Schultz

AU - Harris, Alex K.

AU - Rychly, David J.

AU - Ergul, Adviye

PY - 2005/4/29

Y1 - 2005/4/29

N2 - Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. Despite overwhelming evidence on the damaging consequences of oxidative stress and its role in experimental diabetes, large scale clinical trials with classic antioxidants failed to demonstrate any benefit for diabetic patients. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes.

AB - Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. Despite overwhelming evidence on the damaging consequences of oxidative stress and its role in experimental diabetes, large scale clinical trials with classic antioxidants failed to demonstrate any benefit for diabetic patients. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes.

KW - Antioxidants

KW - Diabetes

KW - Oxidative Stress

UR - http://www.scopus.com/inward/record.url?scp=26844564082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26844564082&partnerID=8YFLogxK

U2 - 10.1186/1475-2840-4-5

DO - 10.1186/1475-2840-4-5

M3 - Review article

C2 - 15862133

AN - SCOPUS:26844564082

VL - 4

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

SN - 1475-2840

M1 - 5

ER -