Oxidative stress in Parkinson's disease: Role in neurodegeneration and targets for therapeutics

Rebecca Banerjee, Navneet Ammal Kaidery, Bobby Thomas

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative movement disorder affecting millions of predominantly elderly people worldwide and remains essentially untreatable. The underlying mechanisms of selective dopaminergic neurodegeneration in the substantia nigra pars compacta in PD are still poorly understood and the sufferings of the victims of the disease are unimaginable. Intense research endeavors have been directed in delineating the molecular events in the etiopathogenesis of PD. Oxidative stress stands at the forefront amongst several plausible hypotheses of PD pathogenesis in terms of the volume and substantiality of evidence acquired through controlled technologically advanced studies of the human disease and the experimental models of PD. Despite ample evidence in support of the involvement of oxidative stress in PD pathogenesis, traditional antioxidant-based therapeutic strategies have failed in the clinic. Here we discuss lessons learnt from these failed clinical trials and new promising antioxidant-based neuroprotective strategies for therapeutic approaches that may usher hope to win the battle against this debilitating disease.

Original languageEnglish (US)
Title of host publicationOxidative Stress
Subtitle of host publicationDiagnostics, Prevention, and Therapy Volume 2
EditorsSilvana Andreescu, Maria Hepel
PublisherAmerican Chemical Society
Pages147-176
Number of pages30
ISBN (Electronic)9780841231009
DOIs
StatePublished - Jan 1 2015

Publication series

NameACS Symposium Series
Volume1200
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

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Oxidative stress
Antioxidants

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Banerjee, R., Kaidery, N. A., & Thomas, B. (2015). Oxidative stress in Parkinson's disease: Role in neurodegeneration and targets for therapeutics. In S. Andreescu, & M. Hepel (Eds.), Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2 (pp. 147-176). (ACS Symposium Series; Vol. 1200). American Chemical Society. https://doi.org/10.1021/bk-2015-1200.ch005

Oxidative stress in Parkinson's disease : Role in neurodegeneration and targets for therapeutics. / Banerjee, Rebecca; Kaidery, Navneet Ammal; Thomas, Bobby.

Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. ed. / Silvana Andreescu; Maria Hepel. American Chemical Society, 2015. p. 147-176 (ACS Symposium Series; Vol. 1200).

Research output: Chapter in Book/Report/Conference proceedingChapter

Banerjee, R, Kaidery, NA & Thomas, B 2015, Oxidative stress in Parkinson's disease: Role in neurodegeneration and targets for therapeutics. in S Andreescu & M Hepel (eds), Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. ACS Symposium Series, vol. 1200, American Chemical Society, pp. 147-176. https://doi.org/10.1021/bk-2015-1200.ch005
Banerjee R, Kaidery NA, Thomas B. Oxidative stress in Parkinson's disease: Role in neurodegeneration and targets for therapeutics. In Andreescu S, Hepel M, editors, Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. American Chemical Society. 2015. p. 147-176. (ACS Symposium Series). https://doi.org/10.1021/bk-2015-1200.ch005
Banerjee, Rebecca ; Kaidery, Navneet Ammal ; Thomas, Bobby. / Oxidative stress in Parkinson's disease : Role in neurodegeneration and targets for therapeutics. Oxidative Stress: Diagnostics, Prevention, and Therapy Volume 2. editor / Silvana Andreescu ; Maria Hepel. American Chemical Society, 2015. pp. 147-176 (ACS Symposium Series).
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