Oxygen distributions partly explain the radiation response of human squamous cell carcinomas.

P. Okunieff, J. de Bie, E. P. Dunphy, D. J. Terris, M. Höckel

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The oxygen tension of human tumours has often been thought to alter tumour response to radiation therapy. The purpose of this analysis is to determine to what extent the observed results of radiotherapy fit predictions based on in situ human tumour pO2 distributions. The radiation dose-response curve for patients treated with radiation alone for squamous cell cancers of the cervix and oropharynx were calculated based on published data. pO2 histograms were obtained from 30 women with cervical cancer and 11 patients with neck nodes from head and neck cancers. An average of 76 +/- 35 (range 28-174) measurements were made from each patient. Hypoxia was assumed to be a purely dose-modifying factor with a maximum OER of 2.5. Assuming patients are treated with daily radiation doses of 2 Gy, the squamous cell carcinoma alpha/beta ratio is 10 Gy, and that tumours have a mean of 10(8) clonogens, it was possible to estimate tumour control probability. Tumour oxygenation was an extremely important modifier of the slope of the dose-response curve and alone was sufficient to account for the slope of the clinically observed dose-response curve for neck nodes. The response curve for uterine cervical cancers is very shallow, and the oxygen distribution did not completely account for heterogeneity of response of these tumours. The results support the conclusion that oxygen tension distribution is an important modifier of human radiation treatment response.

Original languageEnglish (US)
Pages (from-to)S185-90
Number of pages6
JournalThe British journal of cancer. Supplement
Volume27
Issue numberSUPPL. XXVII
StatePublished - Jul 1 1996

Fingerprint

Squamous Cell Carcinoma
Radiation
Oxygen
Neoplasms
Uterine Cervical Neoplasms
Neck
Radiotherapy
Oropharyngeal Neoplasms
Squamous Cell Neoplasms
Head and Neck Neoplasms

Keywords

  • Human tumours
  • Hypoxia
  • Oxygenation
  • Tumour control probability

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Oxygen distributions partly explain the radiation response of human squamous cell carcinomas. / Okunieff, P.; de Bie, J.; Dunphy, E. P.; Terris, D. J.; Höckel, M.

In: The British journal of cancer. Supplement, Vol. 27, No. SUPPL. XXVII, 01.07.1996, p. S185-90.

Research output: Contribution to journalArticle

Okunieff, P, de Bie, J, Dunphy, EP, Terris, DJ & Höckel, M 1996, 'Oxygen distributions partly explain the radiation response of human squamous cell carcinomas.', The British journal of cancer. Supplement, vol. 27, no. SUPPL. XXVII, pp. S185-90.
Okunieff, P. ; de Bie, J. ; Dunphy, E. P. ; Terris, D. J. ; Höckel, M. / Oxygen distributions partly explain the radiation response of human squamous cell carcinomas. In: The British journal of cancer. Supplement. 1996 ; Vol. 27, No. SUPPL. XXVII. pp. S185-90.
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