Oxygen, free radicals, and the kidney

Paul M O'Connor, Carlos M. Schreck, Roger G. Evans

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The kidneys are unique in that oxygen delivery far outweighs metabolic demand. As a result, renal O2 extraction is normally low (∼15 % compared with ∼35-40 % in most tissues), and tissue O2 tension is relatively high, particularly within the highly perfused renal cortical region. Reactive oxygen species play an important role in normal cellular function, and excess production of reactive oxygen species (oxidative stress) can lead to the development of disease. It is well established that the rate of production of reactive oxygen species varies with O2 tension. In this chapter, we review the known molecular sources of reactive oxygen species within the kidney and their dependence on O2 tension. Included in this discussion, we will review the unique physiology of the kidney and how this affects renal O2 tension and the production of reactive oxygen species. We will also review the pathophysiological relationship between the development of renal hypoxia and production of reactive oxygen species within the kidney.

Original languageEnglish (US)
Title of host publicationSystems Biology of Free Radicals and Antioxidants
PublisherSpringer-Verlag Berlin Heidelberg
Pages2563-2580
Number of pages18
ISBN (Electronic)9783642300189
ISBN (Print)3642300170, 9783642300172
DOIs
Publication statusPublished - May 1 2012

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Keywords

  • Hydrogen peroxide
  • Modeling
  • Reactive oxygen species
  • Renal
  • Superoxide

ASJC Scopus subject areas

  • Medicine(all)

Cite this

O'Connor, P. M., Schreck, C. M., & Evans, R. G. (2012). Oxygen, free radicals, and the kidney. In Systems Biology of Free Radicals and Antioxidants (pp. 2563-2580). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_112