P-selectin Glycoprotein Ligand-1 Plays a Crucial Role in the Selective Recruitment of Leukocytes Into the Atherosclerotic Arterial Wall

Yuqing Huo, Lijun Xia

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Leukocyte recruitment to the arterial vessel wall is the first step in the development of atherosclerotic lesions. Leukocyte homing in this event proceeds through a well-defined adhesion cascade, which includes tethering, rolling, adhesion, and transmigration. Selectins, including the P-, E-, and L-selectins, and their ligands mediate the initial tethering and rolling. Interactions between selectins and their ligands serve as a braking system to decelerate fast-flowing leukocytes from the central blood stream and enable them to adhere to and transmigrate underneath the activated endothelium. The best characterized ligand for selectins is P-selectin glycoprotein ligand-1, an extended homodimeric mucin on leukocytes that binds to all three selectins. Recent studies show that differential expression or glycosylation of P-selectin glycoprotein ligand-1 in different leukocytes mediates selective recruitment of different subsets of monocytes or lymphocytes to atherosclerotic arteries.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume19
Issue number4
DOIs
StatePublished - May 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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