P-selectin Glycoprotein Ligand-1 Plays a Crucial Role in the Selective Recruitment of Leukocytes Into the Atherosclerotic Arterial Wall

Yuqing Huo, Lijun Xia

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Leukocyte recruitment to the arterial vessel wall is the first step in the development of atherosclerotic lesions. Leukocyte homing in this event proceeds through a well-defined adhesion cascade, which includes tethering, rolling, adhesion, and transmigration. Selectins, including the P-, E-, and L-selectins, and their ligands mediate the initial tethering and rolling. Interactions between selectins and their ligands serve as a braking system to decelerate fast-flowing leukocytes from the central blood stream and enable them to adhere to and transmigrate underneath the activated endothelium. The best characterized ligand for selectins is P-selectin glycoprotein ligand-1, an extended homodimeric mucin on leukocytes that binds to all three selectins. Recent studies show that differential expression or glycosylation of P-selectin glycoprotein ligand-1 in different leukocytes mediates selective recruitment of different subsets of monocytes or lymphocytes to atherosclerotic arteries.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume19
Issue number4
DOIs
StatePublished - May 1 2009

Fingerprint

Leukocytes
Selectins
Ligands
L-Selectin
P-Selectin
E-Selectin
Mucins
Glycosylation
Endothelium
Monocytes
Arteries
P-selectin ligand protein
Lymphocytes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

P-selectin Glycoprotein Ligand-1 Plays a Crucial Role in the Selective Recruitment of Leukocytes Into the Atherosclerotic Arterial Wall. / Huo, Yuqing; Xia, Lijun.

In: Trends in Cardiovascular Medicine, Vol. 19, No. 4, 01.05.2009, p. 140-145.

Research output: Contribution to journalReview article

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abstract = "Leukocyte recruitment to the arterial vessel wall is the first step in the development of atherosclerotic lesions. Leukocyte homing in this event proceeds through a well-defined adhesion cascade, which includes tethering, rolling, adhesion, and transmigration. Selectins, including the P-, E-, and L-selectins, and their ligands mediate the initial tethering and rolling. Interactions between selectins and their ligands serve as a braking system to decelerate fast-flowing leukocytes from the central blood stream and enable them to adhere to and transmigrate underneath the activated endothelium. The best characterized ligand for selectins is P-selectin glycoprotein ligand-1, an extended homodimeric mucin on leukocytes that binds to all three selectins. Recent studies show that differential expression or glycosylation of P-selectin glycoprotein ligand-1 in different leukocytes mediates selective recruitment of different subsets of monocytes or lymphocytes to atherosclerotic arteries.",
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