p16 and ARF

activation of teenage proteins in old age.

Satyanarayana Ande, K. Lenhard Rudolph

Research output: Contribution to journalComment/debate

Abstract

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

Original languageEnglish (US)
Pages (from-to)1237-1240
Number of pages4
JournalThe Journal of clinical investigation
Volume114
Issue number9
StatePublished - Nov 1 2004
Externally publishedYes

Fingerprint

Telomere Shortening
Retinoblastoma Protein
Cell Aging
Cell Cycle
Up-Regulation
Cell Proliferation
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

p16 and ARF : activation of teenage proteins in old age. / Ande, Satyanarayana; Rudolph, K. Lenhard.

In: The Journal of clinical investigation, Vol. 114, No. 9, 01.11.2004, p. 1237-1240.

Research output: Contribution to journalComment/debate

@article{2c18f0c85c9549f8a940c0b4768e64ca,
title = "p16 and ARF: activation of teenage proteins in old age.",
abstract = "Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.",
author = "Satyanarayana Ande and Rudolph, {K. Lenhard}",
year = "2004",
month = "11",
day = "1",
language = "English (US)",
volume = "114",
pages = "1237--1240",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "9",

}

TY - JOUR

T1 - p16 and ARF

T2 - activation of teenage proteins in old age.

AU - Ande, Satyanarayana

AU - Rudolph, K. Lenhard

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

AB - Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus--p16INK4a and ARF--arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging.

UR - http://www.scopus.com/inward/record.url?scp=15244360933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15244360933&partnerID=8YFLogxK

M3 - Comment/debate

VL - 114

SP - 1237

EP - 1240

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 9

ER -