p16 and ARF

Activation of teenage proteins in old age

Satyanarayana Ande, Karl Lenhard Rudolph

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Cellular senescence induced by different stresses and telomere shortening appears to play an important role in the aging process. The products of the INK4a/ARF locus - p16INK4a and ARF - arrest cell proliferation at the senescence stage by exerting their effects on retinoblastoma protein- and p53-mediated responsive pathways. A study in this issue of the JCI provides experimental evidence of a specific upregulation of these cell cycle inhibitors in a variety of organs during mammalian aging (see the related article beginning on page 1299).

Original languageEnglish (US)
Pages (from-to)1237-1240
Number of pages4
JournalJournal of Clinical Investigation
Volume114
Issue number9
DOIs
StatePublished - Jan 1 2004

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Telomere Shortening
Retinoblastoma Protein
Cell Aging
Cell Cycle
Up-Regulation
Cell Proliferation
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

p16 and ARF : Activation of teenage proteins in old age. / Ande, Satyanarayana; Rudolph, Karl Lenhard.

In: Journal of Clinical Investigation, Vol. 114, No. 9, 01.01.2004, p. 1237-1240.

Research output: Contribution to journalReview article

Ande, Satyanarayana ; Rudolph, Karl Lenhard. / p16 and ARF : Activation of teenage proteins in old age. In: Journal of Clinical Investigation. 2004 ; Vol. 114, No. 9. pp. 1237-1240.
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