P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion

Anna Goc, Ahmad Al-Azayzih, Maha Abdalla, Belal Al-Husein, Sravan Kumar Kavuri, Jeffrey R Lee, Kelvin Moses, Payaningal R. Somanath

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: The significance of Pak1 in prostate cancer remains unclear. Results: Pak1 knockdown impaired prostate tumor growth via increased expression of TGFβ and reduced secretion of MMP9. Conclusions: We demonstrated that Pak1 is a more potent mediator of prostate cancer cell migration and tumor growth than Pak6, the predominant isoform in the prostate. Significance: A novel role of Pak1 in prostate cancer is identified.

Original languageEnglish (US)
Pages (from-to)3025-3035
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number5
DOIs
StatePublished - Feb 1 2013

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p21-Activated Kinases
Matrix Metalloproteinase 9
Transforming Growth Factors
Tumors
Prostate
Prostatic Neoplasms
Growth
Neoplasms
Cell Movement
Protein Isoforms
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. / Goc, Anna; Al-Azayzih, Ahmad; Abdalla, Maha; Al-Husein, Belal; Kavuri, Sravan Kumar; Lee, Jeffrey R; Moses, Kelvin; Somanath, Payaningal R.

In: Journal of Biological Chemistry, Vol. 288, No. 5, 01.02.2013, p. 3025-3035.

Research output: Contribution to journalArticle

Goc, Anna ; Al-Azayzih, Ahmad ; Abdalla, Maha ; Al-Husein, Belal ; Kavuri, Sravan Kumar ; Lee, Jeffrey R ; Moses, Kelvin ; Somanath, Payaningal R. / P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 5. pp. 3025-3035.
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AU - Kavuri, Sravan Kumar

AU - Lee, Jeffrey R

AU - Moses, Kelvin

AU - Somanath, Payaningal R.

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