p53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations

James T. Castle, Massimo Cardinali, F. James Kratochvil, Susan L. Abbondanzo, Harvey P. Kessler, Paul L. Auclair, William Andrew Yeudall

Research output: Contribution to journalArticle

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Abstract

Objective. Recent epidemiologic studies have identified a trend of increasing cancer incidence in younger patients. The purpose of this study was to determine whether this might be reflected by different molecular mechanisms for tumor development. Study design. Dysplastic and malignant oral lesions from age-distinct patient populations were immunohistochemically analyzed for expression of p53 and cyclin D1. Chi-square analysis was used to determine statistical significance. Results. Eighty-two percent of "older" and 75% of "younger" carcinomas stained positively with p53; 63% of carcinomas in the older population and 55% of carcinomas in the younger population showed cyclin D1 positivity. Dysplasias showed similar cyclin D1 staining in both groups. Interestingly, 100% of "younger" dysplasias stained positively for p53, whereas 35.3% of "older" dysplastic lesions showed immunoreactivity. Staining of carcinomas was not statistically significant, whereas p53 staining of dysplasias proved highly significant (P < .025). Conclusions. p53 immunoreactivity is detectable at an earlier stage of carcinogenesis in younger patients than in the traditional risk population for oral cancer.

Original languageEnglish (US)
Pages (from-to)326-332
Number of pages7
JournalOral surgery, oral medicine, oral pathology, oral radiology, and endodontics
Volume88
Issue number3
DOIs
StatePublished - Jan 1 1999

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Cyclin D1
Staining and Labeling
Carcinoma
Population
Mouth Neoplasms
Epidemiologic Studies
Neoplasms
Carcinogenesis
Incidence

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

p53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations. / Castle, James T.; Cardinali, Massimo; Kratochvil, F. James; Abbondanzo, Susan L.; Kessler, Harvey P.; Auclair, Paul L.; Yeudall, William Andrew.

In: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Vol. 88, No. 3, 01.01.1999, p. 326-332.

Research output: Contribution to journalArticle

Castle, James T. ; Cardinali, Massimo ; Kratochvil, F. James ; Abbondanzo, Susan L. ; Kessler, Harvey P. ; Auclair, Paul L. ; Yeudall, William Andrew. / p53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations. In: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 1999 ; Vol. 88, No. 3. pp. 326-332.
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AU - Kessler, Harvey P.

AU - Auclair, Paul L.

AU - Yeudall, William Andrew

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N2 - Objective. Recent epidemiologic studies have identified a trend of increasing cancer incidence in younger patients. The purpose of this study was to determine whether this might be reflected by different molecular mechanisms for tumor development. Study design. Dysplastic and malignant oral lesions from age-distinct patient populations were immunohistochemically analyzed for expression of p53 and cyclin D1. Chi-square analysis was used to determine statistical significance. Results. Eighty-two percent of "older" and 75% of "younger" carcinomas stained positively with p53; 63% of carcinomas in the older population and 55% of carcinomas in the younger population showed cyclin D1 positivity. Dysplasias showed similar cyclin D1 staining in both groups. Interestingly, 100% of "younger" dysplasias stained positively for p53, whereas 35.3% of "older" dysplastic lesions showed immunoreactivity. Staining of carcinomas was not statistically significant, whereas p53 staining of dysplasias proved highly significant (P < .025). Conclusions. p53 immunoreactivity is detectable at an earlier stage of carcinogenesis in younger patients than in the traditional risk population for oral cancer.

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