p53: Its mutations and their impact on transcription

Catherine Vaughan, Isabella Pearsall, Andrew Yeudall, Swati Palit Deb, Sumitra Deb

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

p53 is a tumor suppressor protein whose key function is to maintain the integrity of the cell. Mutations in p53 have been found in up to 50 % of all human cancers and cause an increase in oncogenic phenotypes such as proliferation and tumorigenicity. Both wild-type and mutant p53 have been shown to transactivate their target genes, either through directly binding to DNA, or indirectly through protein-protein interactions. This review discusses possible mechanisms behind both wild-type and mutant p53-mediated transactivation and touches on the concept of addiction to mutant p53 of cancer cells and how that may be used for future therapies.

Original languageEnglish (US)
Pages (from-to)71-90
Number of pages20
JournalSub-Cellular Biochemistry
Volume85
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

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Keywords

  • Gain-of-function
  • Mutant p53
  • Oncogenesis
  • Transactivation
  • Transcription
  • Tumor suppressor
  • p53

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

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