p53 mutation in the genesis of metastasis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Development of metastatic cancer is a complex series of events that includes genesis of tumor-related vascular and lymphatic systems, enhanced cellular motility, and the capacity to invade and survive at distant sites, as well as evasion of host defences. The wild-type p53 protein plays key roles in controlling these facets of tumor progression, and loss of normal p53 function can be sufficient to predispose tumor cells to gain metastatic properties. In contrast, dominant p53 mutants that have gained oncogenic functions can actively drive metastasis through a variety of mechanisms. This chapter aims to highlight these processes.

Original languageEnglish (US)
Pages (from-to)105-117
Number of pages13
JournalSubcellular Biochemistry
Volume85
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Tumors
Neoplasm Metastasis
Mutation
Neoplasms
Lymphatic System
Cells
Blood Vessels
Proteins

Keywords

  • Chemokine
  • Epithelial-mesenchymal transition
  • Extracellular matrix
  • G-protein
  • microRNA
  • Motility
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

Cite this

p53 mutation in the genesis of metastasis. / Yeudall, William Andrew.

In: Subcellular Biochemistry, Vol. 85, 01.01.2014, p. 105-117.

Research output: Contribution to journalArticle

@article{ebff60d531994bfdbbede1d71366ecb1,
title = "p53 mutation in the genesis of metastasis",
abstract = "Development of metastatic cancer is a complex series of events that includes genesis of tumor-related vascular and lymphatic systems, enhanced cellular motility, and the capacity to invade and survive at distant sites, as well as evasion of host defences. The wild-type p53 protein plays key roles in controlling these facets of tumor progression, and loss of normal p53 function can be sufficient to predispose tumor cells to gain metastatic properties. In contrast, dominant p53 mutants that have gained oncogenic functions can actively drive metastasis through a variety of mechanisms. This chapter aims to highlight these processes.",
keywords = "Chemokine, Epithelial-mesenchymal transition, Extracellular matrix, G-protein, microRNA, Motility, Transforming growth factor beta",
author = "Yeudall, {William Andrew}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-94-017-9211-0_6",
language = "English (US)",
volume = "85",
pages = "105--117",
journal = "Sub-Cellular Biochemistry",
issn = "0306-0225",
publisher = "Plenum Publishers",

}

TY - JOUR

T1 - p53 mutation in the genesis of metastasis

AU - Yeudall, William Andrew

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Development of metastatic cancer is a complex series of events that includes genesis of tumor-related vascular and lymphatic systems, enhanced cellular motility, and the capacity to invade and survive at distant sites, as well as evasion of host defences. The wild-type p53 protein plays key roles in controlling these facets of tumor progression, and loss of normal p53 function can be sufficient to predispose tumor cells to gain metastatic properties. In contrast, dominant p53 mutants that have gained oncogenic functions can actively drive metastasis through a variety of mechanisms. This chapter aims to highlight these processes.

AB - Development of metastatic cancer is a complex series of events that includes genesis of tumor-related vascular and lymphatic systems, enhanced cellular motility, and the capacity to invade and survive at distant sites, as well as evasion of host defences. The wild-type p53 protein plays key roles in controlling these facets of tumor progression, and loss of normal p53 function can be sufficient to predispose tumor cells to gain metastatic properties. In contrast, dominant p53 mutants that have gained oncogenic functions can actively drive metastasis through a variety of mechanisms. This chapter aims to highlight these processes.

KW - Chemokine

KW - Epithelial-mesenchymal transition

KW - Extracellular matrix

KW - G-protein

KW - microRNA

KW - Motility

KW - Transforming growth factor beta

UR - http://www.scopus.com/inward/record.url?scp=84922393434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922393434&partnerID=8YFLogxK

U2 - 10.1007/978-94-017-9211-0_6

DO - 10.1007/978-94-017-9211-0_6

M3 - Article

VL - 85

SP - 105

EP - 117

JO - Sub-Cellular Biochemistry

JF - Sub-Cellular Biochemistry

SN - 0306-0225

ER -