Paclitaxel: New uses for an old drug

Dongshan Zhang, Ruhao Yang, Shixuan Wang, Zheng Dong

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Paclitaxel (Taxol), one of the most important anticancer drugs, has been used for therapy of different types of cancers. Mechanistically, paclitaxel arrests cell cycle and induces cell death by stabilizing microtubules and interfering with microtubule disassembly in cell division. Recently, it has been found that low-dose paclitaxel seems promising in treating non-cancer diseases, such as skin disorders, renal and hepatic fibrosis, inflammation, axon regeneration, limb salvage, and coronary artery restenosis. Future studies need to understand the mechanisms underlying these effects in order to design therapies with specificity.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalDrug Design, Development and Therapy
Volume8
DOIs
StatePublished - Feb 20 2014

Keywords

  • Coronary artery restenosis
  • Fibrosis
  • Kidney
  • Limb salvage
  • Taxol inflammation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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