Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles

Carlos P. Griswold, Nisaraporn Suthiwangcharoen, Steven M. Pochini, Chad E. Stephens

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladiumcatalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.

Original languageEnglish (US)
Pages (from-to)1672-1681
Number of pages10
JournalSynthetic Communications
Volume41
Issue number11
DOIs
StatePublished - May 11 2011

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Pyrimidinones
Palladium
Amines
Electrons

Keywords

  • 2-Aminopyrrole
  • DPEphos
  • N-arylation
  • Palladium-catalyzed
  • Pyrrolo[2,3-d] pyrido[1,2-a]pyrimidine
  • Xantphos

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles. / Griswold, Carlos P.; Suthiwangcharoen, Nisaraporn; Pochini, Steven M.; Stephens, Chad E.

In: Synthetic Communications, Vol. 41, No. 11, 11.05.2011, p. 1672-1681.

Research output: Contribution to journalArticle

Griswold, Carlos P. ; Suthiwangcharoen, Nisaraporn ; Pochini, Steven M. ; Stephens, Chad E. / Palladium-catalyzed N-arylation of 3-functionalized 2-amino-4,5- dimethylpyrroles. In: Synthetic Communications. 2011 ; Vol. 41, No. 11. pp. 1672-1681.
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