Pancreatic tumors show high levels of hypoxia

Albert C. Koong, Vivek K. Mehta, Quynh T. Le, George A. Fisher, David J Terris, J. Martin Brown, Augusto J. Bastidas, Mark Vierra

Research output: Contribution to journalArticle

307 Citations (Scopus)

Abstract

Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalInternational Journal of Radiation Oncology Biology Physics
Volume48
Issue number4
DOIs
StatePublished - Nov 1 2000
Externally publishedYes

Fingerprint

hypoxia
tumors
Pancreas
pancreas
oxygenation
Neoplasms
Pancreatic Neoplasms
cancer
Germany
Electrodes
Adenocarcinoma
therapy
Hypoxia
electrodes
Tumor Hypoxia
Therapeutics

Keywords

  • Adenocarcinoma
  • Hypoxia
  • Oxygenation
  • Pancreas

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Koong, A. C., Mehta, V. K., Le, Q. T., Fisher, G. A., Terris, D. J., Brown, J. M., ... Vierra, M. (2000). Pancreatic tumors show high levels of hypoxia. International Journal of Radiation Oncology Biology Physics, 48(4), 919-922. https://doi.org/10.1016/S0360-3016(00)00803-8

Pancreatic tumors show high levels of hypoxia. / Koong, Albert C.; Mehta, Vivek K.; Le, Quynh T.; Fisher, George A.; Terris, David J; Brown, J. Martin; Bastidas, Augusto J.; Vierra, Mark.

In: International Journal of Radiation Oncology Biology Physics, Vol. 48, No. 4, 01.11.2000, p. 919-922.

Research output: Contribution to journalArticle

Koong, AC, Mehta, VK, Le, QT, Fisher, GA, Terris, DJ, Brown, JM, Bastidas, AJ & Vierra, M 2000, 'Pancreatic tumors show high levels of hypoxia', International Journal of Radiation Oncology Biology Physics, vol. 48, no. 4, pp. 919-922. https://doi.org/10.1016/S0360-3016(00)00803-8
Koong, Albert C. ; Mehta, Vivek K. ; Le, Quynh T. ; Fisher, George A. ; Terris, David J ; Brown, J. Martin ; Bastidas, Augusto J. ; Vierra, Mark. / Pancreatic tumors show high levels of hypoxia. In: International Journal of Radiation Oncology Biology Physics. 2000 ; Vol. 48, No. 4. pp. 919-922.
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