Pancreatic tumors show high levels of hypoxia

Albert C. Koong; Vivek K. Mehta; Quynh T. Le; George A. Fisher; David J Terris; J. Martin Brown; Augusto J. Bastidas; Mark Vierra

doi:10.1016/S0360-3016(00)00803-8

Pancreatic tumors show high levels of hypoxia

Albert C. Koong, Vivek K. Mehta, Quynh T. Le, George A. Fisher, David J Terris, J. Martin Brown, Augusto J. Bastidas, Mark Vierra

Research output: Contribution to journal › Article › peer-review

478 Scopus citations

Abstract

Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. Copyright (C) 2000 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	919-922
Number of pages	4
Journal	International Journal of Radiation Oncology Biology Physics
Volume	48
Issue number	4
DOIs	https://doi.org/10.1016/S0360-3016(00)00803-8
State	Published - Nov 1 2000
Externally published	Yes

Keywords

Adenocarcinoma
Hypoxia
Oxygenation
Pancreas

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0360-3016(00)00803-8

Cite this

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title = "Pancreatic tumors show high levels of hypoxia",

abstract = "Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. Copyright (C) 2000 Elsevier Science Inc.",

keywords = "Adenocarcinoma, Hypoxia, Oxygenation, Pancreas",

author = "Koong, {Albert C.} and Mehta, {Vivek K.} and Le, {Quynh T.} and Fisher, {George A.} and Terris, {David J} and Brown, {J. Martin} and Bastidas, {Augusto J.} and Mark Vierra",

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T1 - Pancreatic tumors show high levels of hypoxia

AU - Koong, Albert C.

AU - Mehta, Vivek K.

AU - Le, Quynh T.

AU - Fisher, George A.

AU - Terris, David J

AU - Brown, J. Martin

AU - Bastidas, Augusto J.

AU - Vierra, Mark

PY - 2000/11/1

Y1 - 2000/11/1

N2 - Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. Copyright (C) 2000 Elsevier Science Inc.

AB - Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. Copyright (C) 2000 Elsevier Science Inc.

KW - Adenocarcinoma

KW - Hypoxia

KW - Oxygenation

KW - Pancreas

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ER -

Pancreatic tumors show high levels of hypoxia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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