Pancreatic tumors show high levels of hypoxia

Albert C. Koong, Vivek K. Mehta, Quynh T. Le, George A. Fisher, David J Terris, J. Martin Brown, Augusto J. Bastidas, Mark Vierra

Research output: Contribution to journalArticle

327 Scopus citations

Abstract

Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas, we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven sequential patients with adenocarcinomas of the pancreas consented to intraoperative measurements of tumor oxygenation using the Eppendorf (Hamburg, Germany) polargraphic electrode. Results: All 7 tumors demonstrated significant tumor hypoxia. In contrast, adjacent normal pancreas showed normal oxygenation. Conclusion: Tumor hypoxia exists within pancreatic cancers. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalInternational Journal of Radiation Oncology Biology Physics
Volume48
Issue number4
DOIs
StatePublished - Nov 1 2000
Externally publishedYes

Keywords

  • Adenocarcinoma
  • Hypoxia
  • Oxygenation
  • Pancreas

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    Koong, A. C., Mehta, V. K., Le, Q. T., Fisher, G. A., Terris, D. J., Brown, J. M., Bastidas, A. J., & Vierra, M. (2000). Pancreatic tumors show high levels of hypoxia. International Journal of Radiation Oncology Biology Physics, 48(4), 919-922. https://doi.org/10.1016/S0360-3016(00)00803-8