Paradigm-Shifters: Phosphorylated Prolactin and Short Prolactin Receptors

Kuang Tzu Huang, Eric Ueda, Yen Hao Chen, Ameae M. Walker

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Since the discovery of physiologically-regulated prolactin (PRL) phosphorylation, one focus of the laboratory has been an examination of the different functions of the unmodified and phosphorylated hormone. In the mammary gland, unmodified PRL promotes growth activities, whereas phosphorylated or pseudophosphorylated PRL antagonizes this while also being a superior agonist for changes that favor differentiation. Phosphorylated PRL also increases expression of the short forms of the PRL receptor. These short forms of the receptor have functions beyond the accepted dominant negative and in mammary epithelial cells are capable of generating an intracellular signal leading to increased tight junction formation and β-casein expression.

Original languageEnglish (US)
Pages (from-to)69-79
Number of pages11
JournalJournal of Mammary Gland Biology and Neoplasia
Volume13
Issue number1
DOIs
StatePublished - Mar 1 2008

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Keywords

  • Cell junction
  • Differentiation
  • Extracellular matrix
  • Phosphorylated prolactin
  • S179D prolactin
  • Short prolactin receptors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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