Abstract
Background: Hypercalcemia has been reported in association with a number of malignancies, but it is an unusual manifestation of ovarian cancer. This finding at presentation (possibly aggravated by oral calcium intake) led to discovery of a clear cell carcinoma of the ovary. The implications and pathophysiology of this association are reviewed. Case report: Following presentation with abdominal symptoms, this premenopausal woman was found to have bilateral adnexal masses and hypercalcemia. Her parathormone-related polypeptide was found to be elevated. After surgery and staging, she received adjuvant carboplatin and paclitaxel (later substituted by docetaxel). She has done well on her long-term follow-up. Conclusions: This rare paraneoplastic manifestation of ovarian cancer may be associated with long-term survival if discovered at an early stage. In this instance, further benefit may have been obtained from adjuvant platinum-based chemotherapy. Copyright:
Original language | English (US) |
---|---|
Article number | 271 |
Journal | ecancermedicalscience |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Oct 2 2012 |
Externally published | Yes |
Keywords
- Clear cell adenocarcinoma
- Hypercalcemia
- Ovarian
- PTHrP
- Paraneoplastic
ASJC Scopus subject areas
- Oncology
- Cancer Research