Paraneoplastic hypercalcemia in clear cell ovarian adenocarcinoma

S. Lewin, D. Dezube, A. K. Guddati, K. Mittal, F. Muggia, Paula Klein

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Hypercalcemia has been reported in association with a number of malignancies, but it is an unusual manifestation of ovarian cancer. This finding at presentation (possibly aggravated by oral calcium intake) led to discovery of a clear cell carcinoma of the ovary. The implications and pathophysiology of this association are reviewed. Case report: Following presentation with abdominal symptoms, this premenopausal woman was found to have bilateral adnexal masses and hypercalcemia. Her parathormone-related polypeptide was found to be elevated. After surgery and staging, she received adjuvant carboplatin and paclitaxel (later substituted by docetaxel). She has done well on her long-term follow-up. Conclusions: This rare paraneoplastic manifestation of ovarian cancer may be associated with long-term survival if discovered at an early stage. In this instance, further benefit may have been obtained from adjuvant platinum-based chemotherapy. Copyright:

Original languageEnglish (US)
Article number271
Issue number1
StatePublished - Oct 2 2012
Externally publishedYes


  • Clear cell adenocarcinoma
  • Hypercalcemia
  • Ovarian
  • PTHrP
  • Paraneoplastic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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