Paraneoplastic movement disorders

Shyamal H. Mehta, John Christopher Morgan, Kapil Dev Sethi

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Neurologic paraneoplastic syndromes (NPSs) result from damage to the nervous system due to the remote effects of cancer not related to metastasis, infection, or metabolic derangements. NPSs are rare, affecting 1 in 10,000 patients with cancer. Pathogenesis is likely related to the immune mechanisms: normal neural tissue is mistakenly attacked due to the similarity in the onconeural antigens expressed by the tumor cells. Among the various "classic" and other NPSs, this review focuses on paraneoplastic movement disorders, including ataxia due to cerebellar degeneration, stiffperson syndrome, opsoclonus-myoclonus syndrome, chorea, parkinsonism, and tremor. The recently described syndrome of paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis is also included, given that these patients have complex movements such as stereotypies and dyskinesias in addition to psychiatric symptoms, altered sensorium, and other neurologic signs. Although variable, treatment and prognosis of NPSs rely heavily on treatment of the underlying malignancy and immunotherapy.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalCurrent Neurology and Neuroscience Reports
Volume9
Issue number4
DOIs
StatePublished - Jul 1 2009

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Nervous System Paraneoplastic Syndromes
Movement Disorders
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Opsoclonus-Myoclonus Syndrome
Chorea
Neoplasms
Dyskinesias
Parkinsonian Disorders
Neoplasm Antigens
Tremor
Ataxia
Neurologic Manifestations
Immunotherapy
Nervous System
Psychiatry
Neoplasm Metastasis
Therapeutics
Infection

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Paraneoplastic movement disorders. / Mehta, Shyamal H.; Morgan, John Christopher; Sethi, Kapil Dev.

In: Current Neurology and Neuroscience Reports, Vol. 9, No. 4, 01.07.2009, p. 285-291.

Research output: Contribution to journalReview article

Mehta, Shyamal H. ; Morgan, John Christopher ; Sethi, Kapil Dev. / Paraneoplastic movement disorders. In: Current Neurology and Neuroscience Reports. 2009 ; Vol. 9, No. 4. pp. 285-291.
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