Parasympathetic control of parathyroid hormone and calcitonin secretion in rats

Javier E. Stern, María I. Keller Sarmiento, Daniel P. Cardinali

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cholinergic nerve fibers can be traced to the vicinity of C- and parathyroid cells. The objective of this study was to examine the changes in circulating calcium, parathyroid hormone (PTH) and calcitonin levels after a bilateral surgical section of thyroid (TN) or inferior laryngeal nerves (ILN) in rats. Parasympathetic surgical section decreased significantly thyroid and parathyroid neuronal [3H]choline uptake. A significant fall in total serum calcium and a significant increase in serum PTH were observed 10 days after TN and ILN sections, while calcitonin levels decreased significantly after ILN sections only. When parathyroid sensitivity to a hypocalcemic challenge was assessed, a significantly larger serum PTH response to EDTA was detectable in TN- or ILN-sectioned rats. A significantly smaller hypocalcemia after EDTA was observed in TN-sectioned rats only. Following calcium chloride injection, the increase in serum calcitonin was greater, and the increase in serum calcium levels smaller, in TN-sectioned rats as compared to sham-operated controls. In ILN-sectioned rats, the secretory response of calcitonin and the hypercalcemia achieved after a calcium chloride challenge was significantly greater than in controls. The results indicate that ILN or TN sections induced hypocalcemia and increased serum PTH levels in rats, as well as bringing about a greater secretory response of PTH and calcitonin when challenged with an appropriate stimulus. An inhibitory parasympathetic influence parathyroid and C-cell secretion can be envisioned.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
JournalJournal of the Autonomic Nervous System
Volume48
Issue number1
DOIs
StatePublished - Jun 1994

Fingerprint

Recurrent Laryngeal Nerve
Calcitonin
Parathyroid Hormone
Serum
Calcium Chloride
Hypocalcemia
Calcium
Edetic Acid
Thyroid Gland
Cholinergic Fibers
Hypercalcemia
Choline
Nerve Fibers
Injections

Keywords

  • Calcitonin
  • Calcium homeostasis
  • Inferior laryngeal nerve
  • Parasympathetic nervous system
  • Parathyroid gland
  • Parathyroid hormone
  • Thyroid C cell
  • Thyroid nerve

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

Cite this

Parasympathetic control of parathyroid hormone and calcitonin secretion in rats. / Stern, Javier E.; Keller Sarmiento, María I.; Cardinali, Daniel P.

In: Journal of the Autonomic Nervous System, Vol. 48, No. 1, 06.1994, p. 45-53.

Research output: Contribution to journalArticle

Stern, Javier E. ; Keller Sarmiento, María I. ; Cardinali, Daniel P. / Parasympathetic control of parathyroid hormone and calcitonin secretion in rats. In: Journal of the Autonomic Nervous System. 1994 ; Vol. 48, No. 1. pp. 45-53.
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