TY - JOUR
T1 - Parental history of atopic disease
T2 - Disease pattern and risk of pediatric atopy in offspring
AU - Alford, Sharon Hensley
AU - Zoratti, Edward
AU - Peterson, Edward L.
AU - Maliarik, Mary
AU - Ownby, Dennis R.
AU - Johnson, Christine Cole
N1 - Funding Information:
Supported by the Blue Cross Blue Shield of Michigan Foundation, the National Institute of Allergy and Infectious Diseases (AI50681), the National Heart, Lung, and Blood Institute (HL68971, HL68245, and HL67427), the Fund for Henry Ford Hospital, and the National Institute of Environmental Health Sciences (P03ES06639).
PY - 2004/11
Y1 - 2004/11
N2 - Family history is an important risk factor for atopic disease. However, most studies assess only limited information on family history. Because atopic disease can exhibit transient or persistent patterns, it may be useful to assess information on patterns of disease within families. This approach has been applied in other diseases, such as cancer, to discriminate between predominately inherited versus environmentally caused (sporadic) cases. In a cohort of children who were followed from birth until age 6 to 7 years, we examined the relationship between parental onset (ie, childhood and adulthood) and duration of atopic disease (ie, persistent disease) and the risk of pediatric atopic disease. Our hypothesis was that different parental disease patterns would be important to pediatric risk of disease. Data from 476 families in the ongoing Childhood Allergy Study in Detroit, Mich, were analyzed by using logistic regression. We examined the association between parental patterns of disease and disease onset in their children. Father's disease history, particularly asthma history, was more strongly related to pediatric outcomes than mother's history. Asthma status in the fathers, whether it was childhood-only, adulthood-only, or persistent, was associated with current asthma in the children. Childhood-only and persistent asthma in fathers conferred a higher risk of atopy in the study children, whereas adulthood-only disease did not. There was also a significant relationship between persistent allergy in the father and atopy in the study children. Our data support the hypothesis that there are complex inheritance patterns for allergy and asthma. Therefore, a detailed family history of atopy, including childhood and adulthood experiences, is critical to identifying and classifying risk and disease phenotypes.
AB - Family history is an important risk factor for atopic disease. However, most studies assess only limited information on family history. Because atopic disease can exhibit transient or persistent patterns, it may be useful to assess information on patterns of disease within families. This approach has been applied in other diseases, such as cancer, to discriminate between predominately inherited versus environmentally caused (sporadic) cases. In a cohort of children who were followed from birth until age 6 to 7 years, we examined the relationship between parental onset (ie, childhood and adulthood) and duration of atopic disease (ie, persistent disease) and the risk of pediatric atopic disease. Our hypothesis was that different parental disease patterns would be important to pediatric risk of disease. Data from 476 families in the ongoing Childhood Allergy Study in Detroit, Mich, were analyzed by using logistic regression. We examined the association between parental patterns of disease and disease onset in their children. Father's disease history, particularly asthma history, was more strongly related to pediatric outcomes than mother's history. Asthma status in the fathers, whether it was childhood-only, adulthood-only, or persistent, was associated with current asthma in the children. Childhood-only and persistent asthma in fathers conferred a higher risk of atopy in the study children, whereas adulthood-only disease did not. There was also a significant relationship between persistent allergy in the father and atopy in the study children. Our data support the hypothesis that there are complex inheritance patterns for allergy and asthma. Therefore, a detailed family history of atopy, including childhood and adulthood experiences, is critical to identifying and classifying risk and disease phenotypes.
KW - Allergy
KW - asthma
KW - family history
KW - pediatric
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U2 - 10.1016/j.jaci.2004.08.036
DO - 10.1016/j.jaci.2004.08.036
M3 - Article
C2 - 15536408
AN - SCOPUS:7944233172
SN - 0091-6749
VL - 114
SP - 1046
EP - 1050
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 5
ER -