Parental smoking and alcohol consumption and risk of neuroblastoma

Qiwei Yang, A. F. Olshan, M. L. Bondy, N. R. Shah, B. H. Pollock, R. C. Seeger, A. T. Look, S. L. Cohn

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Previous studies and animal evidence have suggested a relationship between parental tobacco or alcohol use and the risk of some childhood cancers, including neuroblastoma. A case-control study was conducted to investigate the relationship between parental tobacco smoking, alcohol consumption, and risk of neuroblastoma. Cases were children diagnosed with neuroblastoma over the period 1992-1994 at Children's Cancer Group and Pediatric Oncology Group institutions throughout the United States and Canada. One matched control was selected using random-digit dialing. Information on parental smoking and drinking history was obtained from 504 case and 504 control parents by telephone interview. Overall, there was no consistent pattern of association with parental smoking and alcohol consumption. For example, both maternal smoking and drinking during the period from 1 month before pregnancy through breastfeeding had adjusted odds ratios (ORs) of 1.1 [95% confidence interval (CI), 0.8-1.4]. There was no association with paternal smoking (OR, 1.2; 95% CI, 0.8-1.6) or paternal drinking 1 month before conception (OR, 1.0; 95% CI, 0.7-1.4). There was no consistent increase in risk by the amount of smoking or drinking during any time period relative to pregnancy. There was no suggestion of an increased risk when only one parent smoked. Smoking or drinking among both parents did not jointly increase the risk of neuroblastoma in their offspring. The child's age at diagnosis, stage, or MYCN oncogene amplification status did not materially alter the OR estimates. It is concluded that the results from this study do not indicate any evidence for a relationship between neuroblastoma and parental tobacco or alcohol use.

Original languageEnglish (US)
Pages (from-to)967-972
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume9
Issue number9
StatePublished - Oct 16 2000

Fingerprint

Neuroblastoma
Alcohol Drinking
Smoking
Drinking
Odds Ratio
Confidence Intervals
Tobacco
Parents
Alcohols
Pregnancy
Breast Feeding
Oncogenes
Canada
Case-Control Studies
Neoplasms
Mothers
Interviews
Pediatrics

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Yang, Q., Olshan, A. F., Bondy, M. L., Shah, N. R., Pollock, B. H., Seeger, R. C., ... Cohn, S. L. (2000). Parental smoking and alcohol consumption and risk of neuroblastoma. Cancer Epidemiology Biomarkers and Prevention, 9(9), 967-972.

Parental smoking and alcohol consumption and risk of neuroblastoma. / Yang, Qiwei; Olshan, A. F.; Bondy, M. L.; Shah, N. R.; Pollock, B. H.; Seeger, R. C.; Look, A. T.; Cohn, S. L.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 9, No. 9, 16.10.2000, p. 967-972.

Research output: Contribution to journalArticle

Yang, Q, Olshan, AF, Bondy, ML, Shah, NR, Pollock, BH, Seeger, RC, Look, AT & Cohn, SL 2000, 'Parental smoking and alcohol consumption and risk of neuroblastoma', Cancer Epidemiology Biomarkers and Prevention, vol. 9, no. 9, pp. 967-972.
Yang Q, Olshan AF, Bondy ML, Shah NR, Pollock BH, Seeger RC et al. Parental smoking and alcohol consumption and risk of neuroblastoma. Cancer Epidemiology Biomarkers and Prevention. 2000 Oct 16;9(9):967-972.
Yang, Qiwei ; Olshan, A. F. ; Bondy, M. L. ; Shah, N. R. ; Pollock, B. H. ; Seeger, R. C. ; Look, A. T. ; Cohn, S. L. / Parental smoking and alcohol consumption and risk of neuroblastoma. In: Cancer Epidemiology Biomarkers and Prevention. 2000 ; Vol. 9, No. 9. pp. 967-972.
@article{c6066e5b07d944618a0c063a7b24f5f4,
title = "Parental smoking and alcohol consumption and risk of neuroblastoma",
abstract = "Previous studies and animal evidence have suggested a relationship between parental tobacco or alcohol use and the risk of some childhood cancers, including neuroblastoma. A case-control study was conducted to investigate the relationship between parental tobacco smoking, alcohol consumption, and risk of neuroblastoma. Cases were children diagnosed with neuroblastoma over the period 1992-1994 at Children's Cancer Group and Pediatric Oncology Group institutions throughout the United States and Canada. One matched control was selected using random-digit dialing. Information on parental smoking and drinking history was obtained from 504 case and 504 control parents by telephone interview. Overall, there was no consistent pattern of association with parental smoking and alcohol consumption. For example, both maternal smoking and drinking during the period from 1 month before pregnancy through breastfeeding had adjusted odds ratios (ORs) of 1.1 [95{\%} confidence interval (CI), 0.8-1.4]. There was no association with paternal smoking (OR, 1.2; 95{\%} CI, 0.8-1.6) or paternal drinking 1 month before conception (OR, 1.0; 95{\%} CI, 0.7-1.4). There was no consistent increase in risk by the amount of smoking or drinking during any time period relative to pregnancy. There was no suggestion of an increased risk when only one parent smoked. Smoking or drinking among both parents did not jointly increase the risk of neuroblastoma in their offspring. The child's age at diagnosis, stage, or MYCN oncogene amplification status did not materially alter the OR estimates. It is concluded that the results from this study do not indicate any evidence for a relationship between neuroblastoma and parental tobacco or alcohol use.",
author = "Qiwei Yang and Olshan, {A. F.} and Bondy, {M. L.} and Shah, {N. R.} and Pollock, {B. H.} and Seeger, {R. C.} and Look, {A. T.} and Cohn, {S. L.}",
year = "2000",
month = "10",
day = "16",
language = "English (US)",
volume = "9",
pages = "967--972",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "9",

}

TY - JOUR

T1 - Parental smoking and alcohol consumption and risk of neuroblastoma

AU - Yang, Qiwei

AU - Olshan, A. F.

AU - Bondy, M. L.

AU - Shah, N. R.

AU - Pollock, B. H.

AU - Seeger, R. C.

AU - Look, A. T.

AU - Cohn, S. L.

PY - 2000/10/16

Y1 - 2000/10/16

N2 - Previous studies and animal evidence have suggested a relationship between parental tobacco or alcohol use and the risk of some childhood cancers, including neuroblastoma. A case-control study was conducted to investigate the relationship between parental tobacco smoking, alcohol consumption, and risk of neuroblastoma. Cases were children diagnosed with neuroblastoma over the period 1992-1994 at Children's Cancer Group and Pediatric Oncology Group institutions throughout the United States and Canada. One matched control was selected using random-digit dialing. Information on parental smoking and drinking history was obtained from 504 case and 504 control parents by telephone interview. Overall, there was no consistent pattern of association with parental smoking and alcohol consumption. For example, both maternal smoking and drinking during the period from 1 month before pregnancy through breastfeeding had adjusted odds ratios (ORs) of 1.1 [95% confidence interval (CI), 0.8-1.4]. There was no association with paternal smoking (OR, 1.2; 95% CI, 0.8-1.6) or paternal drinking 1 month before conception (OR, 1.0; 95% CI, 0.7-1.4). There was no consistent increase in risk by the amount of smoking or drinking during any time period relative to pregnancy. There was no suggestion of an increased risk when only one parent smoked. Smoking or drinking among both parents did not jointly increase the risk of neuroblastoma in their offspring. The child's age at diagnosis, stage, or MYCN oncogene amplification status did not materially alter the OR estimates. It is concluded that the results from this study do not indicate any evidence for a relationship between neuroblastoma and parental tobacco or alcohol use.

AB - Previous studies and animal evidence have suggested a relationship between parental tobacco or alcohol use and the risk of some childhood cancers, including neuroblastoma. A case-control study was conducted to investigate the relationship between parental tobacco smoking, alcohol consumption, and risk of neuroblastoma. Cases were children diagnosed with neuroblastoma over the period 1992-1994 at Children's Cancer Group and Pediatric Oncology Group institutions throughout the United States and Canada. One matched control was selected using random-digit dialing. Information on parental smoking and drinking history was obtained from 504 case and 504 control parents by telephone interview. Overall, there was no consistent pattern of association with parental smoking and alcohol consumption. For example, both maternal smoking and drinking during the period from 1 month before pregnancy through breastfeeding had adjusted odds ratios (ORs) of 1.1 [95% confidence interval (CI), 0.8-1.4]. There was no association with paternal smoking (OR, 1.2; 95% CI, 0.8-1.6) or paternal drinking 1 month before conception (OR, 1.0; 95% CI, 0.7-1.4). There was no consistent increase in risk by the amount of smoking or drinking during any time period relative to pregnancy. There was no suggestion of an increased risk when only one parent smoked. Smoking or drinking among both parents did not jointly increase the risk of neuroblastoma in their offspring. The child's age at diagnosis, stage, or MYCN oncogene amplification status did not materially alter the OR estimates. It is concluded that the results from this study do not indicate any evidence for a relationship between neuroblastoma and parental tobacco or alcohol use.

UR - http://www.scopus.com/inward/record.url?scp=0033801250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033801250&partnerID=8YFLogxK

M3 - Article

C2 - 11008916

AN - SCOPUS:0033801250

VL - 9

SP - 967

EP - 972

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 9

ER -