Parkinson's disease

From molecular pathways in disease to therapeutic approaches

Bobby Thomas

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a complex multifactor disease marked by extensive neuropathology in the brain with selective yet prominent and progressive loss of midbrain dopamine neurons. Clinically PD is characterized by motor abnormalities including resting tremor, bradykinesia, altered gait, muscular rigidity, postural instability, together with autonomic dysfunctions. The etiological factors involved in the development of PD are still elusive, but there is considerable evidence that a combination of genetic susceptibilities and environmental factors plays a critical role in disease pathogenesis. The identification of single genes in the past decade linked to heritable forms of PD has challenged the previously held view of a nongenetic etiology for this progressive movement disorder. These genetic breakthroughs have revolutionized the research by providing unique opportunities to pursue novel mechanisms and identified new clues to disease pathogenesis in PD. This forum review provides an update on current hypotheses and recent findings in mitochondrial dysfunction, oxidative damage, innate and adaptive immune systems, protein misfolding and aggregation, and advances in translational approaches to PD. These aspects are reviewed with an aim to promote better understanding of molecular pathways prevalent in parkinsonian brain that will eventually aide in development of promising therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)2077-2082
Number of pages6
JournalAntioxidants and Redox Signaling
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2009

Fingerprint

Parkinson Disease
Therapeutics
Muscle Rigidity
Hypokinesia
Dopaminergic Neurons
Brain
Movement Disorders
Tremor
Genetic Predisposition to Disease
Mesencephalon
Gait
Immune System
Immune system
Rigidity
Neurons
Dopamine
Agglomeration
Genes
Research
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Parkinson's disease : From molecular pathways in disease to therapeutic approaches. / Thomas, Bobby.

In: Antioxidants and Redox Signaling, Vol. 11, No. 9, 01.09.2009, p. 2077-2082.

Research output: Contribution to journalReview article

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