Passive transfer of hepatitis antibodies during intravenous administration of immune globulin

P. Karna, D. L. Murray, D. Valduss, N. Mattarella, J. W. Dyke, G. A. Maier

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We studied the effect of intravenous immune globulin (IVIG) infusion on the levels of hepatitis B and C antibodies in 10 premature babies. All four tested lots of a commercially purchased IVIG preparation were found to contain substantial amounts of hepatitis B core and hepatitis C antibodies. Our results show that passive transfer of hepatitis B and C virus antibodies occurred after IVIG infusion, and that the levels were dependent on the quantity of IVIG given. When assessing neonates for hepatitis, the factor of receipt of blood products, including IVIG, needs to be considered to interpret laboratory results.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalThe Journal of Pediatrics
Volume125
Issue number3
DOIs
Publication statusPublished - Jan 1 1994

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Karna, P., Murray, D. L., Valduss, D., Mattarella, N., Dyke, J. W., & Maier, G. A. (1994). Passive transfer of hepatitis antibodies during intravenous administration of immune globulin. The Journal of Pediatrics, 125(3), 463-465. https://doi.org/10.1016/S0022-3476(05)83296-2