TY - JOUR
T1 - Paternal age and mortality in nonaffective psychosis
AU - Miller, Brian
AU - Pihlajamaa, Johanna
AU - Haukka, Jari
AU - Cannon, Mary
AU - Henriksson, Markus
AU - Heilä, Hannele
AU - Huttunen, Matti
AU - Tanskanen, Antti
AU - Lönnqvist, Jouko
AU - Suvisaari, Jaana
AU - Kirkpatrick, Brian
PY - 2010/8
Y1 - 2010/8
N2 - Introduction: Advanced paternal age (APA) is associated with an increased mortality in the general population, and is a risk factor for schizophrenia. We aimed to test if APA is associated with increased mortality in people with nonaffective psychosis. Methods: Subjects with nonaffective psychosis who were born in Helsinki, Finland, between 1951 and 1960 (n=529) were followed until June 2006 (age 46 to 55). Hazard ratios were calculated, adjusting for subject age, age of the other parent, and gender. Results: In females but not males, there was a significant increase in all-causes mortality (HR=7.04, 95% CI 1.60-31.04, p=0.01) and natural deaths (HR=7.64, 95% CI 1.20-48.66, p=0.03) in offspring of fathers age ≤40, after adjustment for potential confounders. In males but not females, there was a significant decrease in suicides (HR=0.89, 95% CI 0.81-0.97, p=0.01) with increasing maternal age (as a continuous variable). In the entire sample, there was also a trend for decreased all-cause mortality (HR=0.96, 95% CI 0.92-1.01, p=0.08) with increasing maternal age (as a continuous variable). Discussion: Both paternal and maternal age may affect mortality risk in offspring with psychosis. The specific disorders and pathway(s) associated with the increase in natural cause mortality remain to be determined.
AB - Introduction: Advanced paternal age (APA) is associated with an increased mortality in the general population, and is a risk factor for schizophrenia. We aimed to test if APA is associated with increased mortality in people with nonaffective psychosis. Methods: Subjects with nonaffective psychosis who were born in Helsinki, Finland, between 1951 and 1960 (n=529) were followed until June 2006 (age 46 to 55). Hazard ratios were calculated, adjusting for subject age, age of the other parent, and gender. Results: In females but not males, there was a significant increase in all-causes mortality (HR=7.04, 95% CI 1.60-31.04, p=0.01) and natural deaths (HR=7.64, 95% CI 1.20-48.66, p=0.03) in offspring of fathers age ≤40, after adjustment for potential confounders. In males but not females, there was a significant decrease in suicides (HR=0.89, 95% CI 0.81-0.97, p=0.01) with increasing maternal age (as a continuous variable). In the entire sample, there was also a trend for decreased all-cause mortality (HR=0.96, 95% CI 0.92-1.01, p=0.08) with increasing maternal age (as a continuous variable). Discussion: Both paternal and maternal age may affect mortality risk in offspring with psychosis. The specific disorders and pathway(s) associated with the increase in natural cause mortality remain to be determined.
KW - Gender differences
KW - Longitudinal studies
KW - Mortality
KW - Nonaffective psychosis
KW - Paternal age
KW - Schizophrenia
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U2 - 10.1016/j.schres.2010.01.020
DO - 10.1016/j.schres.2010.01.020
M3 - Article
C2 - 20163936
AN - SCOPUS:77955055326
SN - 0920-9964
VL - 121
SP - 218
EP - 226
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -