Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors

Yoshikatsu Kaneko, Falk Nimmerjahn, Michael P. Madaio, Jeffrey V. Ravetch

Research output: Contribution to journalArticle

190 Scopus citations

Abstract

Introduction of heterologous anti-glomerular basement membrane antiserum (nephrotoxic serum, NTS) into presensitized mice triggers the production of IgG anti-NTS antibodies that are predominantly IgG2b and the glomerular deposition of pathogenic immune complexes, leading to accelerated renal disease. The pathology observed in this model is determined by the effector cell activation threshold that is established by the coexpression on infiltrating macrophages of the IgG2a/2b restricted activation receptor FcγRIV and its inhibitory receptor counterpart, FcγRIIB. Blocking FcaγRIV with a specific monoclonal antibody thereby preventing IgG2b engagement or treatment with high dose intravenous γ-globulin (IVIG) to down-regulate FcγRIV while up-regulating FcγRIIB, protects mice from fatal disease. In the absence of FcγRIIB, IVIG is not protective; this indicates that reduced FcγRIV expression alone is insufficient to protect animals from pathogenic IgG2b immune complexes. These results establish the significance of specific IgG subclasses and their cognate FcγRs in renal disease. JEM

Original languageEnglish (US)
Pages (from-to)789-797
Number of pages9
JournalJournal of Experimental Medicine
Volume203
Issue number3
DOIs
StatePublished - Mar 20 2006

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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