TY - JOUR
T1 - Pathophysiology of varicocele in nonhuman primates
T2 - Long-term seminal and testicular changes
AU - Harrison, R. M.
AU - Lewis, R. W.
AU - Roberts, J. A.
N1 - Funding Information:
Received January 15, 1986; revised and accepted March 27, 1986. *Supported by grant R01 HD 12939 from the National Institute of Child Health and Human Development and grant RR 00164 from the National Institutes of Health. tReprint requests: Richard M. Harrison, Ph.D., Delta Primate Center, Tulane University, Covington, Louisiana 70433.
PY - 1986
Y1 - 1986
N2 - Varicocele was surgically induced in monkeys to study the long-term effects of the condition on seminal and testicular parameters. Sperm motility was depressed but improved after varicocelectomy. Sperm concentration was less affected, but sperm morphology showed long-term degenerative changes, i.e., for more than 2 years. Testicular blood flow was depressed acutely but returned to normal after 2 years. Electron microscopy showed changes in the basal lamina and spermatogonia that persisted throughout the study. Left adrenalectomy, at the time of varicocele induction, did not alter the development of varicocele-related changes. The sequence of changes suggests that the effects of this experimental varicocele may be reversed in the monkey model through changes in collateral and ancillary revascularization.
AB - Varicocele was surgically induced in monkeys to study the long-term effects of the condition on seminal and testicular parameters. Sperm motility was depressed but improved after varicocelectomy. Sperm concentration was less affected, but sperm morphology showed long-term degenerative changes, i.e., for more than 2 years. Testicular blood flow was depressed acutely but returned to normal after 2 years. Electron microscopy showed changes in the basal lamina and spermatogonia that persisted throughout the study. Left adrenalectomy, at the time of varicocele induction, did not alter the development of varicocele-related changes. The sequence of changes suggests that the effects of this experimental varicocele may be reversed in the monkey model through changes in collateral and ancillary revascularization.
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U2 - 10.1016/s0015-0282(16)49594-4
DO - 10.1016/s0015-0282(16)49594-4
M3 - Article
C2 - 3743802
AN - SCOPUS:0022549104
SN - 0015-0282
VL - 46
SP - 500
EP - 510
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -