Patient characteristics, treatment patterns, and mortality in elderly patients newly diagnosed with acute myeloid leukemia meeting ineligibility criteria for high intensity chemotherapy

Shuling Li, Yuanyuan Ji, Yi Peng, Vamsi Kota, Christopher Kim

Research output: Contribution to journalArticlepeer-review

Abstract

To describe patient characteristics, treatment patterns, and survival among elderly patients (≥66 years) newly diagnosed with acute myeloid leukemia (AML) meeting ≥1 ineligibility criteria for high-intensity chemotherapy (HIC; i.e. age >75 years, cardiac disease/prior anthracycline therapy, or secondary AML), we analyzed 2007–2017 100% Medicare hematologic cancer data. Patients were stratified based on whether they received HIC or low-intensity chemotherapy (LIC) or best supportive care (BSC) within 60 days after AML diagnosis. Of 4,152 patients, 43.2% received chemotherapy, 33.8% BSC, and 23.1% no therapy. Among chemotherapy-treated patients, HIC was more common than LIC (58.8 vs 41.2%), despite targeting patients meeting ≥1 ineligibility criteria for HIC. Poor overall survival was observed for patients receiving chemotherapy and BSC (median overall survival [interquartile range]: HIC, 1.9 [0.8, 6.6] months; LIC, 3.8 [1.4, 9.3] months; BSC, 1.0 [0.4, 2.5] months). Results highlight the need for additional effective and tolerable treatments for this population.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalLeukemia and Lymphoma
Volume63
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Acute myeloid leukemia
  • chemotherapy
  • elderly
  • real-world evidence
  • survival outcomes
  • treatment patterns

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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