Patterns of sodium excretion during sympathetic nervous system arousal

Gregory A Harshfield, Derrick A. Pulliam, Bruce S. Alpert

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The purpose of this study was to examine Na+ handling and regulation during 1 hour of behaviorally induced sympathetic nervous system (SNS) arousal followed by 2 hours of recovery. Two patterns of response were observed among experimental subjects, despite similar changes in blood pressure and heart rate. In one group (n=19), Na+ excretion increased significantly during SNS arousal, which then decreased significantly during recovery (12.3 versus 16.0 versus 13.1 meq/hr, baseline, SNS arousal, recovery, respectively). Changes in Na+ excretion were correlated with changes in creatinine clearance from baseline to SNS arousal (r=0.54) and SNS arousal to recovery (r=0.58), and were accompanied by significant increases in plasma renin activity (1.5 versus 2.0 ng/ml/hr) and aldosterone (8.5 versus 10.3 ng/ml/hr) from baseline to SNS arousal. Na+ excretion decreased during SNS arousal in the other group of subjects (n=17) and remained below baseline levels during recovery (16.2 versus 12.7 versus 11.9 meq/hr). These changes were associated with significant decreases in creatinine clearance from baseline to recovery (138 versus 121 ml/min/1.73 m2) and significant increases in plasma renin activity from baseline to SNS arousal (1.3 versus 2.2 ng/ml/hr) but not in aldosterone. Control subjects (n=24) maintained baseline levels of each variable throughout the procedure These results suggest that individuals differ in Na+ handling and regulation during behavioral arousal. Decreases in Na+ have been reported previously in humans and animals at risk for the development of hypertension.

Original languageEnglish (US)
Pages (from-to)1156-1160
Number of pages5
JournalHypertension
Volume17
Issue number6 SUPPL. 2
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Sympathetic Nervous System
Arousal
Sodium
Aldosterone
Renin
Creatinine
Heart Rate
Blood Pressure
Hypertension

Keywords

  • Blood pressure
  • Essential hypertension
  • Sodium
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Harshfield, G. A., Pulliam, D. A., & Alpert, B. S. (1991). Patterns of sodium excretion during sympathetic nervous system arousal. Hypertension, 17(6 SUPPL. 2), 1156-1160.

Patterns of sodium excretion during sympathetic nervous system arousal. / Harshfield, Gregory A; Pulliam, Derrick A.; Alpert, Bruce S.

In: Hypertension, Vol. 17, No. 6 SUPPL. 2, 01.01.1991, p. 1156-1160.

Research output: Contribution to journalArticle

Harshfield, GA, Pulliam, DA & Alpert, BS 1991, 'Patterns of sodium excretion during sympathetic nervous system arousal', Hypertension, vol. 17, no. 6 SUPPL. 2, pp. 1156-1160.
Harshfield GA, Pulliam DA, Alpert BS. Patterns of sodium excretion during sympathetic nervous system arousal. Hypertension. 1991 Jan 1;17(6 SUPPL. 2):1156-1160.
Harshfield, Gregory A ; Pulliam, Derrick A. ; Alpert, Bruce S. / Patterns of sodium excretion during sympathetic nervous system arousal. In: Hypertension. 1991 ; Vol. 17, No. 6 SUPPL. 2. pp. 1156-1160.
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