Patterns of sodium excretion during sympathetic nervous system arousal

Gregory A. Harshfield, Derrick A. Pulliam, Bruce S. Alpert

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The purpose of this study was to examine Na+ handling and regulation during 1 hour of behaviorally induced sympathetic nervous system (SNS) arousal followed by 2 hours of recovery. Two patterns of response were observed among experimental subjects, despite similar changes in blood pressure and heart rate. In one group (n=19), Na+ excretion increased significantly during SNS arousal, which then decreased significantly during recovery (12.3 versus 16.0 versus 13.1 meq/hr, baseline, SNS arousal, recovery, respectively). Changes in Na+ excretion were correlated with changes in creatinine clearance from baseline to SNS arousal (r=0.54) and SNS arousal to recovery (r=0.58), and were accompanied by significant increases in plasma renin activity (1.5 versus 2.0 ng/ml/hr) and aldosterone (8.5 versus 10.3 ng/ml/hr) from baseline to SNS arousal. Na+ excretion decreased during SNS arousal in the other group of subjects (n=17) and remained below baseline levels during recovery (16.2 versus 12.7 versus 11.9 meq/hr). These changes were associated with significant decreases in creatinine clearance from baseline to recovery (138 versus 121 ml/min/1.73 m2) and significant increases in plasma renin activity from baseline to SNS arousal (1.3 versus 2.2 ng/ml/hr) but not in aldosterone. Control subjects (n=24) maintained baseline levels of each variable throughout the procedure These results suggest that individuals differ in Na+ handling and regulation during behavioral arousal. Decreases in Na+ have been reported previously in humans and animals at risk for the development of hypertension.

Original languageEnglish (US)
Pages (from-to)1156-1160
Number of pages5
JournalHypertension
Volume17
Issue number6 SUPPL. 2
DOIs
StatePublished - Jun 1991

Keywords

  • Blood pressure
  • Essential hypertension
  • Sodium
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

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    Harshfield, G. A., Pulliam, D. A., & Alpert, B. S. (1991). Patterns of sodium excretion during sympathetic nervous system arousal. Hypertension, 17(6 SUPPL. 2), 1156-1160. https://doi.org/10.1161/01.hyp.17.6.1156