Pediatric sports-related concussion produces cerebral blood flow alterations

Todd A. Maugans, Chad Farley, Mekibib Altaye, James Leach, Kim M. Cecil

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The pathophysiology of sports-related concussion (SRC) is incompletely understood. Human adult and experimental animal investigations have revealed structural axonal injuries, decreases in the neuronal metabolite N-acetyl aspartate, and reduced cerebral blood flow (CBF) after SRC and minor traumatic brain injury. The authors of this investigation explore these possibilities after pediatric SRC. PATIENTS AND METHODS: Twelve children, ages 11 to 15 years, who experienced SRC were evaluated by ImPACT neurocognitive testing, T1 and susceptibility weighted MRI, diffusion tensor imaging, proton magnetic resonance spectroscopy, and phase contrast angiography at <72 hours, 14 days, and 30 days or greater after concussion. A similar number of age- and gender-matched controls were evaluated at a single time point. RESULTS: ImPACT results confirmed statistically significant differences in initial total symptom score and reaction time between the SRC and control groups, resolving by 14 days for total symptom score and 30 days for reaction time. No evidence of structural injury was found on qualitative review of MRI. No decreases in neuronal metabolite N-acetyl aspartate or elevation of lactic acid were detected by proton magnetic resonance spectroscopy. Statistically significant alterations in CBF were documented in the SRC group, with reduction in CBF predominating (38 vs 48 mL/100 g per minute; P = .027). Improvement toward control values occurred in only 27% of the participants at 14 days and 64% at >30 days after SRC. CONCLUSIONS: Pediatric SRC is primarily a physiologic injury, affecting CBF significantly without evidence of measurable structural, metabolic neuronal or axonal injury. Further study of CBF mechanisms is needed to explain patterns of recovery.

Original languageEnglish (US)
Pages (from-to)28-37
Number of pages10
JournalPediatrics
Volume129
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

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Cerebrovascular Circulation
Sports
Pediatrics
Wounds and Injuries
Diffusion Tensor Imaging
Angiography

Keywords

  • Cerebral blood flow
  • Concussion
  • Magnetic resonance spectroscopy
  • MRI
  • Pediatrics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Maugans, T. A., Farley, C., Altaye, M., Leach, J., & Cecil, K. M. (2012). Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics, 129(1), 28-37. https://doi.org/10.1542/peds.2011-2083

Pediatric sports-related concussion produces cerebral blood flow alterations. / Maugans, Todd A.; Farley, Chad; Altaye, Mekibib; Leach, James; Cecil, Kim M.

In: Pediatrics, Vol. 129, No. 1, 01.01.2012, p. 28-37.

Research output: Contribution to journalArticle

Maugans, TA, Farley, C, Altaye, M, Leach, J & Cecil, KM 2012, 'Pediatric sports-related concussion produces cerebral blood flow alterations', Pediatrics, vol. 129, no. 1, pp. 28-37. https://doi.org/10.1542/peds.2011-2083
Maugans, Todd A. ; Farley, Chad ; Altaye, Mekibib ; Leach, James ; Cecil, Kim M. / Pediatric sports-related concussion produces cerebral blood flow alterations. In: Pediatrics. 2012 ; Vol. 129, No. 1. pp. 28-37.
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