Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons

H. A. Savchenko, A. A. Vasylevs'kyǐ, K. A. Pluzhnykov, I. V. Korol'kova, Mykola Mamenko, T. M. Volkova, O. P. Maksymiuk, I. A. Boǐchuk, I. V. Hrishyn, O. O. Kryshtal'

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Almost each natural venom comprises a considerable combinatorial library of bioactive substances that have been optimized during evolution. Particular attention is devoted currently on a search for new modulators of ion channels from the venoms of arthropods. We have studied the effect of peptidous compounds of the Lycosa spider venom on the activity of P2X receptors in DRG neurons of rats. As a result, at least 7 proteins modulating various P2X receptor-operated ionic currents in the sensory neurons of rats have been found.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalFiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994)
Volume55
Issue number2
StatePublished - Aug 12 2009
Externally publishedYes

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Spider Venoms
Sensory Receptor Cells
Arthropod Venoms
Peptides
Diagnosis-Related Groups
Venoms
Ion Channels
Neurons
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Savchenko, H. A., Vasylevs'kyǐ, A. A., Pluzhnykov, K. A., Korol'kova, I. V., Mamenko, M., Volkova, T. M., ... Kryshtal', O. O. (2009). Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons. Fiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994), 55(2), 11-16.

Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons. / Savchenko, H. A.; Vasylevs'kyǐ, A. A.; Pluzhnykov, K. A.; Korol'kova, I. V.; Mamenko, Mykola; Volkova, T. M.; Maksymiuk, O. P.; Boǐchuk, I. A.; Hrishyn, I. V.; Kryshtal', O. O.

In: Fiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994), Vol. 55, No. 2, 12.08.2009, p. 11-16.

Research output: Contribution to journalArticle

Savchenko, HA, Vasylevs'kyǐ, AA, Pluzhnykov, KA, Korol'kova, IV, Mamenko, M, Volkova, TM, Maksymiuk, OP, Boǐchuk, IA, Hrishyn, IV & Kryshtal', OO 2009, 'Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons', Fiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994), vol. 55, no. 2, pp. 11-16.
Savchenko HA, Vasylevs'kyǐ AA, Pluzhnykov KA, Korol'kova IV, Mamenko M, Volkova TM et al. Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons. Fiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994). 2009 Aug 12;55(2):11-16.
Savchenko, H. A. ; Vasylevs'kyǐ, A. A. ; Pluzhnykov, K. A. ; Korol'kova, I. V. ; Mamenko, Mykola ; Volkova, T. M. ; Maksymiuk, O. P. ; Boǐchuk, I. A. ; Hrishyn, I. V. ; Kryshtal', O. O. / Peptide components of Geolycosa spider venom modulate P2X receptor activity of rat sensory neurons. In: Fiziolohichnyǐ zhurnal (Kiev, Ukraine : 1994). 2009 ; Vol. 55, No. 2. pp. 11-16.
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