Perfusion CT investigation of chronic internal carotid artery occlusion: Comparison with SPECT

Nobuhiko Miyazawa, Ali Syed Arbab, Takako Umeda, Iwao Akiyama

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This study investigated the usefulness of perfusion computed tomography (CT) for the evaluation of patients with chronic internal carotid artery (ICA) occlusion by comparing the findings with those of iodine-123 iodoamphetamine ([123I]IMP) single photon emission computed tomography (SPECT). Twenty five patients with chronic ICA occlusion were investigated on the same day by perfusion CT to measure the cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transient time (MTT), and [123I]IMP SPECT to measure the regional CBF, significant correlations were observed between regional CBF measured by SPECT and CBF measured by perfusion CT (r = 0.659, R2 = 0.434, p < 0.001), regional CBF and CBV (r = -0.406, R 2 = 0.165, p < 0.001) and regional CBF and MTT (r = -0.592, R 2 = 0.350, p < 0.001). Significant correlations were also observed between CBF and CBV (r = -0.153, R2 = 0.023, p < 0.001), CBF and MTT (r = -0.580, R2 = 0.337, p < 0.001) and MTT and CBV (r = 0.763, R2 = 0.582, p < 0.001). Perfusion CT is useful to evaluate the hemodynamic state of patients with chronic major cerebral artery occlusive disorders.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalClinical Neurology and Neurosurgery
Issue number1
StatePublished - Dec 2005
Externally publishedYes


  • Cerebral ischemia
  • Computed tomography
  • Perfusion
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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