TY - JOUR
T1 - Perfusion CT investigation of chronic internal carotid artery occlusion
T2 - Comparison with SPECT
AU - Miyazawa, Nobuhiko
AU - Arbab, Ali Syed
AU - Umeda, Takako
AU - Akiyama, Iwao
PY - 2005/12
Y1 - 2005/12
N2 - This study investigated the usefulness of perfusion computed tomography (CT) for the evaluation of patients with chronic internal carotid artery (ICA) occlusion by comparing the findings with those of iodine-123 iodoamphetamine ([123I]IMP) single photon emission computed tomography (SPECT). Twenty five patients with chronic ICA occlusion were investigated on the same day by perfusion CT to measure the cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transient time (MTT), and [123I]IMP SPECT to measure the regional CBF, significant correlations were observed between regional CBF measured by SPECT and CBF measured by perfusion CT (r = 0.659, R2 = 0.434, p < 0.001), regional CBF and CBV (r = -0.406, R 2 = 0.165, p < 0.001) and regional CBF and MTT (r = -0.592, R 2 = 0.350, p < 0.001). Significant correlations were also observed between CBF and CBV (r = -0.153, R2 = 0.023, p < 0.001), CBF and MTT (r = -0.580, R2 = 0.337, p < 0.001) and MTT and CBV (r = 0.763, R2 = 0.582, p < 0.001). Perfusion CT is useful to evaluate the hemodynamic state of patients with chronic major cerebral artery occlusive disorders.
AB - This study investigated the usefulness of perfusion computed tomography (CT) for the evaluation of patients with chronic internal carotid artery (ICA) occlusion by comparing the findings with those of iodine-123 iodoamphetamine ([123I]IMP) single photon emission computed tomography (SPECT). Twenty five patients with chronic ICA occlusion were investigated on the same day by perfusion CT to measure the cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transient time (MTT), and [123I]IMP SPECT to measure the regional CBF, significant correlations were observed between regional CBF measured by SPECT and CBF measured by perfusion CT (r = 0.659, R2 = 0.434, p < 0.001), regional CBF and CBV (r = -0.406, R 2 = 0.165, p < 0.001) and regional CBF and MTT (r = -0.592, R 2 = 0.350, p < 0.001). Significant correlations were also observed between CBF and CBV (r = -0.153, R2 = 0.023, p < 0.001), CBF and MTT (r = -0.580, R2 = 0.337, p < 0.001) and MTT and CBV (r = 0.763, R2 = 0.582, p < 0.001). Perfusion CT is useful to evaluate the hemodynamic state of patients with chronic major cerebral artery occlusive disorders.
KW - Cerebral ischemia
KW - Computed tomography
KW - Perfusion
KW - Single photon emission computed tomography
UR - http://www.scopus.com/inward/record.url?scp=28444483650&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28444483650&partnerID=8YFLogxK
U2 - 10.1016/j.clineuro.2004.12.024
DO - 10.1016/j.clineuro.2004.12.024
M3 - Article
C2 - 16098657
AN - SCOPUS:28444483650
SN - 0303-8467
VL - 108
SP - 11
EP - 17
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 1
ER -