Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial

Chang Sung Kim, Seong Ho Choi, Kyoo Sung Cho, Jung Kiu Chai, Ulf M E Wikesjö, Chong Kwan Kim

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Aim: Autogenous bone grafts and bone biomaterials are being used as part of protocols aiming at reconstruction of periodontal defects. There is a limited biologic information on the effect of such materials on periodontal healing, in particular aberrant healing events that may prevent their general use. The objective of this study was, using histological techniques, to evaluate periodontal healing with focus on root resorption and ankylosis following implantation of autogenous bone and a coral-derived biomaterial into intra-bony defects in dogs. Methods: One-wall intra-bony periodontal defects were surgically created at the distal aspect of the second and the mesial aspect of the fourth mandibular premolars in either right or left jaw quadrants in four Beagle dogs. Each animal received particulated autogenous bone and the resorbable calcium carbonate biomaterial into discrete one-wall intra-bony defects. The mucoperiosteal flaps were positioned and sutured to their pre-surgery position. The animals were euthanized 8 weeks post-surgery when block sections of the defect sites were collected and prepared for qualitative histological analysis. Results: There were no significant differences in periodontal healing between sites receiving autograft bone and the coral-derived biomaterial. A well-organized periodontal ligament bridging new bone and cementum regeneration was observed extending coronal to a notch prepared to delineate the apical extent of the defect. Osteoid and bone with enclosed osteocytes were formed onto the surface of both autograft and coral particles. Although small resorption pits were evident in most teeth, importantly none of the biomaterials provoked marked root resorption. Ankylosis was not observed. Conclusion: Particulated autogenous bone and the coral-derived biomaterial may be implanted into periodontal defects without significant healing aberrations such as root resorption and ankylosis. The histopathological evaluation suggests that the autogenous bone graft has a limited osteogenic potential as demonstrated in this study model.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalJournal of Clinical Periodontology
Volume32
Issue number6
DOIs
StatePublished - Jun 1 2005

Fingerprint

Anthozoa
Biocompatible Materials
Dogs
Bone and Bones
Root Resorption
Ankylosis
Autografts
Transplants
Histological Techniques
Dental Cementum
Osteocytes
Periodontal Ligament
Bone Regeneration
Calcium Carbonate
Bicuspid
Jaw
Tooth

Keywords

  • Ankylosis
  • Autogenous bone
  • Bone grafting
  • Calcium carbonate
  • Dogs
  • Histology
  • Intra-bony defect
  • Root resorption

ASJC Scopus subject areas

  • Periodontics

Cite this

Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial. / Kim, Chang Sung; Choi, Seong Ho; Cho, Kyoo Sung; Chai, Jung Kiu; Wikesjö, Ulf M E; Kim, Chong Kwan.

In: Journal of Clinical Periodontology, Vol. 32, No. 6, 01.06.2005, p. 583-589.

Research output: Contribution to journalArticle

Kim, Chang Sung ; Choi, Seong Ho ; Cho, Kyoo Sung ; Chai, Jung Kiu ; Wikesjö, Ulf M E ; Kim, Chong Kwan. / Periodontal healing in one-wall intra-bony defects in dogs following implantation of autogenous bone or a coral-derived biomaterial. In: Journal of Clinical Periodontology. 2005 ; Vol. 32, No. 6. pp. 583-589.
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AU - Kim, Chang Sung

AU - Choi, Seong Ho

AU - Cho, Kyoo Sung

AU - Chai, Jung Kiu

AU - Wikesjö, Ulf M E

AU - Kim, Chong Kwan

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AB - Aim: Autogenous bone grafts and bone biomaterials are being used as part of protocols aiming at reconstruction of periodontal defects. There is a limited biologic information on the effect of such materials on periodontal healing, in particular aberrant healing events that may prevent their general use. The objective of this study was, using histological techniques, to evaluate periodontal healing with focus on root resorption and ankylosis following implantation of autogenous bone and a coral-derived biomaterial into intra-bony defects in dogs. Methods: One-wall intra-bony periodontal defects were surgically created at the distal aspect of the second and the mesial aspect of the fourth mandibular premolars in either right or left jaw quadrants in four Beagle dogs. Each animal received particulated autogenous bone and the resorbable calcium carbonate biomaterial into discrete one-wall intra-bony defects. The mucoperiosteal flaps were positioned and sutured to their pre-surgery position. The animals were euthanized 8 weeks post-surgery when block sections of the defect sites were collected and prepared for qualitative histological analysis. Results: There were no significant differences in periodontal healing between sites receiving autograft bone and the coral-derived biomaterial. A well-organized periodontal ligament bridging new bone and cementum regeneration was observed extending coronal to a notch prepared to delineate the apical extent of the defect. Osteoid and bone with enclosed osteocytes were formed onto the surface of both autograft and coral particles. Although small resorption pits were evident in most teeth, importantly none of the biomaterials provoked marked root resorption. Ankylosis was not observed. Conclusion: Particulated autogenous bone and the coral-derived biomaterial may be implanted into periodontal defects without significant healing aberrations such as root resorption and ankylosis. The histopathological evaluation suggests that the autogenous bone graft has a limited osteogenic potential as demonstrated in this study model.

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