Periodontal repair in dogs

A biosabsorbable calcium carbonate coral implant enhances space provision of alveolar bone regeneration in conjunction with guided tissue regeneration

Ulf M E Wikesjö, Won Hee Lim, Saghi S. Razi, Thorarinn J. Sigurdsson, Michael B. Lee, Dimitris N. Tatakis, W. Ross Hardwick

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Collapse or compression of a barrier device into a periodontal defect or onto the root surface compromises outcomes following guided tissue regeneration (GTR). Bone biomaterials have been suggested to support regeneration of alveolar bone and to improve space provision with GTR devices. The objective of this study was to evaluate space provision, alveolar bone, and cementum regeneration following use of a bioabsorbable, calcium carbonate biomaterial in conjunction with GTR. Methods: Routine, critical size, 5 to 6 mm, supraalveolar, periodontal defects were created in 5 young adult beagle dogs. Alternate jaw quadrants in consecutive animals received GTR and the coral biomaterial (cGTR) or GTR alone. The animals were euthanized 4 weeks postsurgery and tissue blocks processed for histometric analysis. Results: The coral implant particles were surrounded by newly-formed bone or immersed in connective tissue and appeared to resorb and be replaced by bone. There was limited, if any, appreciable cementum regeneration. Space provision was enhanced in cGTR compared to GTR sites (6.1 ± 1.6 versus 2.4 ± 0.8 mm2; P<0.05). Bone regeneration (height) was significantly increased in cGTR compared to GTR sites averaging 1.9 ± 0.6 and 1.2 ± 0.6 mm, respectively (P<0.05). Bone regeneration (area) was 2-fold greater in cGTR sites compared to the GTR control (3.3 ± 1.8 versus 1.4 ± 0.5 mm2), however the difference was not statistically significant (P>0.05). Conclusions: The coral implant significantly enhanced space provision for GTR while alveolar bone formation appeared to be enhanced by its use. Increased healing intervals are needed to fully understand the biologic value of the coral implant as an adjunct to GTR.

Original languageEnglish (US)
Pages (from-to)957-964
Number of pages8
JournalJournal of Periodontology
Volume74
Issue number7
DOIs
StatePublished - Jul 1 2003

Fingerprint

Guided Tissue Regeneration
Anthozoa
Bone Regeneration
Calcium Carbonate
Dogs
Biocompatible Materials
Dental Cementum
Bone and Bones
Equipment and Supplies
Jaw
Osteogenesis
Connective Tissue
Regeneration
Young Adult

Keywords

  • Alveolar bone
  • Bone regeneration
  • Calcium carbonate
  • Dental cementum
  • Guided bone regeneration
  • Membranes, bioabsorbable

ASJC Scopus subject areas

  • Periodontics

Cite this

Periodontal repair in dogs : A biosabsorbable calcium carbonate coral implant enhances space provision of alveolar bone regeneration in conjunction with guided tissue regeneration. / Wikesjö, Ulf M E; Lim, Won Hee; Razi, Saghi S.; Sigurdsson, Thorarinn J.; Lee, Michael B.; Tatakis, Dimitris N.; Hardwick, W. Ross.

In: Journal of Periodontology, Vol. 74, No. 7, 01.07.2003, p. 957-964.

Research output: Contribution to journalArticle

Wikesjö, Ulf M E ; Lim, Won Hee ; Razi, Saghi S. ; Sigurdsson, Thorarinn J. ; Lee, Michael B. ; Tatakis, Dimitris N. ; Hardwick, W. Ross. / Periodontal repair in dogs : A biosabsorbable calcium carbonate coral implant enhances space provision of alveolar bone regeneration in conjunction with guided tissue regeneration. In: Journal of Periodontology. 2003 ; Vol. 74, No. 7. pp. 957-964.
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abstract = "Background: Collapse or compression of a barrier device into a periodontal defect or onto the root surface compromises outcomes following guided tissue regeneration (GTR). Bone biomaterials have been suggested to support regeneration of alveolar bone and to improve space provision with GTR devices. The objective of this study was to evaluate space provision, alveolar bone, and cementum regeneration following use of a bioabsorbable, calcium carbonate biomaterial in conjunction with GTR. Methods: Routine, critical size, 5 to 6 mm, supraalveolar, periodontal defects were created in 5 young adult beagle dogs. Alternate jaw quadrants in consecutive animals received GTR and the coral biomaterial (cGTR) or GTR alone. The animals were euthanized 4 weeks postsurgery and tissue blocks processed for histometric analysis. Results: The coral implant particles were surrounded by newly-formed bone or immersed in connective tissue and appeared to resorb and be replaced by bone. There was limited, if any, appreciable cementum regeneration. Space provision was enhanced in cGTR compared to GTR sites (6.1 ± 1.6 versus 2.4 ± 0.8 mm2; P<0.05). Bone regeneration (height) was significantly increased in cGTR compared to GTR sites averaging 1.9 ± 0.6 and 1.2 ± 0.6 mm, respectively (P<0.05). Bone regeneration (area) was 2-fold greater in cGTR sites compared to the GTR control (3.3 ± 1.8 versus 1.4 ± 0.5 mm2), however the difference was not statistically significant (P>0.05). Conclusions: The coral implant significantly enhanced space provision for GTR while alveolar bone formation appeared to be enhanced by its use. Increased healing intervals are needed to fully understand the biologic value of the coral implant as an adjunct to GTR.",
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T2 - A biosabsorbable calcium carbonate coral implant enhances space provision of alveolar bone regeneration in conjunction with guided tissue regeneration

AU - Wikesjö, Ulf M E

AU - Lim, Won Hee

AU - Razi, Saghi S.

AU - Sigurdsson, Thorarinn J.

AU - Lee, Michael B.

AU - Tatakis, Dimitris N.

AU - Hardwick, W. Ross

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