Periodontal Repair in Dogs: Evaluation of rhBMP-2 Carriers

Thorarinn J. Sigurdsson, Lauralee Nygaard, Dimitris N. Tatakis, Earl Fu, Thomas J. Turek, Lisa Jin, John M. Wozney, Ulf M E Wikesjö

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

This study evaluated candidate carriers for recombinant human bone morphogenetic protein-2 (rhBMP-2)-driven periodontal regeneration. Previous experiments indicated the ability of rhBMP-2 in a particulate delivery system to result In substantial regeneration of bone and periodontal attachment. In the present study, canine demineralized bone matrix (DBM). bovine deorganified crystalline bone matrix (Bio-Oss), on absorbable collagen sponge (ACS) of type I bovine collagen. poly(D,L-lactide-coglycolide) microparticles (PLGA), and polylactic acid granules (Drilac) were tested for their ability to support rhBMP-2 (0.2 mg/mL implant volume)-driven periodontal regeneration. The implants were tested in routine critical size canine supra-alveolar periodontal defects with transgingival tooth positioning. Contralateral defects in six beagle dogs were semirandomly assigned to receive: DBM/rhBMP-2. DBM (no rhBMP-2), Bio-Oss/rhBMP-2, ACS/rhBMP-2. PLGA/rhBMP-2, or Drilac/rhBMP-2. Animals were sacrificed 8 weeks postsurgery, and block sections of the defects were processed for light microscopy. Substantial bone regeneration was observed in all defects implanted with rhBMP-2. Other measures of periodontal healing. Including cementum regeneration and presence of ankylosis, were more variable between the implants. DBM and BioOss performed well as carriers for rhBMP-2-driven periodontal regeneration, although other impediments to their clinical use exist. This study indicates that qualities of the carrier system, including its space-maintaining capacity, can affect the ability of rhBMP-2 to regenerate both alveolar bone and periodontal attachment.

Original languageEnglish (US)
Pages (from-to)525-537
Number of pages13
JournalInternational Journal of Periodontics and Restorative Dentistry
Volume16
Issue number6
StatePublished - Dec 1 1996

Fingerprint

Dogs
Bone Matrix
Regeneration
Bone Regeneration
Porifera
recombinant human bone morphogenetic protein-2
Canidae
Collagen
Dental Cementum
Ankylosis
Collagen Type I
Microscopy
Tooth
Light
Bone and Bones
Bio-Oss

ASJC Scopus subject areas

  • Oral Surgery
  • Periodontics

Cite this

Sigurdsson, T. J., Nygaard, L., Tatakis, D. N., Fu, E., Turek, T. J., Jin, L., ... Wikesjö, U. M. E. (1996). Periodontal Repair in Dogs: Evaluation of rhBMP-2 Carriers. International Journal of Periodontics and Restorative Dentistry, 16(6), 525-537.

Periodontal Repair in Dogs : Evaluation of rhBMP-2 Carriers. / Sigurdsson, Thorarinn J.; Nygaard, Lauralee; Tatakis, Dimitris N.; Fu, Earl; Turek, Thomas J.; Jin, Lisa; Wozney, John M.; Wikesjö, Ulf M E.

In: International Journal of Periodontics and Restorative Dentistry, Vol. 16, No. 6, 01.12.1996, p. 525-537.

Research output: Contribution to journalArticle

Sigurdsson, TJ, Nygaard, L, Tatakis, DN, Fu, E, Turek, TJ, Jin, L, Wozney, JM & Wikesjö, UME 1996, 'Periodontal Repair in Dogs: Evaluation of rhBMP-2 Carriers', International Journal of Periodontics and Restorative Dentistry, vol. 16, no. 6, pp. 525-537.
Sigurdsson TJ, Nygaard L, Tatakis DN, Fu E, Turek TJ, Jin L et al. Periodontal Repair in Dogs: Evaluation of rhBMP-2 Carriers. International Journal of Periodontics and Restorative Dentistry. 1996 Dec 1;16(6):525-537.
Sigurdsson, Thorarinn J. ; Nygaard, Lauralee ; Tatakis, Dimitris N. ; Fu, Earl ; Turek, Thomas J. ; Jin, Lisa ; Wozney, John M. ; Wikesjö, Ulf M E. / Periodontal Repair in Dogs : Evaluation of rhBMP-2 Carriers. In: International Journal of Periodontics and Restorative Dentistry. 1996 ; Vol. 16, No. 6. pp. 525-537.
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