TY - JOUR
T1 - Periodontal repair in surgically created intrabony defects in dogs
T2 - Influence of the number of bone walls on healing response
AU - Kim, Chang Sung
AU - Choi, Seong Ho
AU - Chai, Jung Kiu
AU - Cho, Kyoo Sung
AU - Moon, Ik Sang
AU - Wikesjö, Ulf M E
AU - Kim, Chong Kwan
PY - 2004/2
Y1 - 2004/2
N2 - Background: The objective of this study was to histologically evaluate periodontal healing following flap surgery in intrabony periodontal defects to determine the influence of the number of bone walls on periodontal regeneration. Methods: One-, 2-, and 3-wall intrabony periodontal defects were surgically produced at the proximal aspect of mandibular premolars in either right or left jaw quadrants in six beagle dogs. Mucoperiosteal flaps were positioned and sutured to their presurgery position following defect preparation. The animals were euthanized at 8 weeks post-surgery, and block sections of the defect sites were collected for histologic and histometric analysis. Results: Bone and cementum regeneration was positively correlated to the number of bone walls limiting the intrabony periodontal defects. The junctional epithelium averaged (±SD) 1.5 ± 0.2, 1.2 ± 0.3, and 0.9 ± 0.2 mm for the 1-, 2-, and 3-wall defects, respectively, with the 3-wall defects being significantly different from the 1-wall defects (P <0.05). Cementum regeneration averaged 1.2 ± 0.6, 2.0 ± 0.6, and 2.8 ± 0.5 mm for the 1-, 2-, and 3-wall defects, respectively; all groups were significantly different from each other (P <0.05). Bone regeneration averaged 1.5 ± 0.5, 1.7 ± 0.6, and 2.3 ± 0.5 mm for the 1-, 2-, and 3-wall defects, respectively, with the 3-wall defects being significantly different from the 1-wall defects (P <0.05). Conclusions: The results suggest that the number of bone walls is a critical factor determining treatment outcomes in intrabony periodontal defects. One- and 3-wall intrabony defects appear to be reproducible models to evaluate candidate technologies for periodontal regeneration.
AB - Background: The objective of this study was to histologically evaluate periodontal healing following flap surgery in intrabony periodontal defects to determine the influence of the number of bone walls on periodontal regeneration. Methods: One-, 2-, and 3-wall intrabony periodontal defects were surgically produced at the proximal aspect of mandibular premolars in either right or left jaw quadrants in six beagle dogs. Mucoperiosteal flaps were positioned and sutured to their presurgery position following defect preparation. The animals were euthanized at 8 weeks post-surgery, and block sections of the defect sites were collected for histologic and histometric analysis. Results: Bone and cementum regeneration was positively correlated to the number of bone walls limiting the intrabony periodontal defects. The junctional epithelium averaged (±SD) 1.5 ± 0.2, 1.2 ± 0.3, and 0.9 ± 0.2 mm for the 1-, 2-, and 3-wall defects, respectively, with the 3-wall defects being significantly different from the 1-wall defects (P <0.05). Cementum regeneration averaged 1.2 ± 0.6, 2.0 ± 0.6, and 2.8 ± 0.5 mm for the 1-, 2-, and 3-wall defects, respectively; all groups were significantly different from each other (P <0.05). Bone regeneration averaged 1.5 ± 0.5, 1.7 ± 0.6, and 2.3 ± 0.5 mm for the 1-, 2-, and 3-wall defects, respectively, with the 3-wall defects being significantly different from the 1-wall defects (P <0.05). Conclusions: The results suggest that the number of bone walls is a critical factor determining treatment outcomes in intrabony periodontal defects. One- and 3-wall intrabony defects appear to be reproducible models to evaluate candidate technologies for periodontal regeneration.
KW - Animal studies
KW - Periodontal diseases/surgery
KW - Periodontal regeneration
KW - Surgical flaps
KW - Wound healing
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U2 - 10.1902/jop.2004.75.2.229
DO - 10.1902/jop.2004.75.2.229
M3 - Article
C2 - 15068110
AN - SCOPUS:1642336280
SN - 0022-3492
VL - 75
SP - 229
EP - 235
JO - Journal of periodontology
JF - Journal of periodontology
IS - 2
ER -