Periodontitis is associated with preeclampsia in pregnant women

Adolfo Contreras, J. A. Herrera, J. E. Soto, Roger Mauricio Arce Munoz, A. Jaramillo, J. E. Botero

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Background: Recent investigations have demonstrated a itive association between periodontitis and pregnancy complications. The purpose of this study was to determine the effect of periodontitis and the subgingival microbial composition on preeclampsia. Methods: A case-control study was carried out in Cali, Colombia that included 130 preeclamptic and 243 non-preeclamptic women between 26 to 36 weeks of pregnancy. Sociodemographic data, obstetric risk factors, periodontal status, and subgingival microbial composition were determined in both groups. Preeclampsia was defined as blood pressure ≥140/90 mm Hg, and ≥2+ proteinuria, confirmed by 0.3 g proteinuria/24 hours of urine specimens. Controls were healthy pregnant women. Odds ratios (ORs) for periodontitis and subgingival microbiota compositions were calculated. Results: A total of 83 out of 130 preeclamptic women (63.8%) and 89 out of 243 controls (36.6%) had chronic periodontitis (OR: 3.0; 95% confidence interval (CI): 1.91 to 4.87; P<0.001). Clinical attachment loss increased in the case group (4.0 ± 0.10 mm) compared to the control group (3.0 ± 0.08 mm) (P <0.001). The average newborn birth weight from preeclamptic mothers was 2.453 g, whereas in controls was 2.981 g (P<0.001). Two red complex microorganisms, Porphyromonas gingivalis and Tannerella forsythensis, and the green complex microorganism Eikenella corrodens were more prevalent in the preeclamptic group than in controls (P <0.01). Conclusions: Chronic periodontal disease and the presence of P. gingivalis, T. forsythensis, and E. corrodens were significantly associated with preeclampsia in pregnant women. Further research is needed to establish pathogenic mechanisms of active periodontal disease and subgingival periodontopathogens related to preeclampsia development.

Original languageEnglish (US)
Pages (from-to)182-188
Number of pages7
JournalJournal of periodontology
Volume77
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

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Periodontitis
Pre-Eclampsia
Pregnant Women
Eikenella corrodens
Porphyromonas gingivalis
Periodontal Diseases
Proteinuria
Odds Ratio
Chronic Periodontitis
Control Groups
Colombia
Pregnancy Complications
Microbiota
Birth Weight
Obstetrics
Case-Control Studies
Chronic Disease
Mothers
Urine
Newborn Infant

Keywords

  • Bacteria
  • Case-control study
  • Infection
  • Periodontitis
  • Preeclampsia

ASJC Scopus subject areas

  • Periodontics

Cite this

Contreras, A., Herrera, J. A., Soto, J. E., Arce Munoz, R. M., Jaramillo, A., & Botero, J. E. (2006). Periodontitis is associated with preeclampsia in pregnant women. Journal of periodontology, 77(2), 182-188. https://doi.org/10.1902/jop.2006.050020

Periodontitis is associated with preeclampsia in pregnant women. / Contreras, Adolfo; Herrera, J. A.; Soto, J. E.; Arce Munoz, Roger Mauricio; Jaramillo, A.; Botero, J. E.

In: Journal of periodontology, Vol. 77, No. 2, 01.02.2006, p. 182-188.

Research output: Contribution to journalArticle

Contreras, A, Herrera, JA, Soto, JE, Arce Munoz, RM, Jaramillo, A & Botero, JE 2006, 'Periodontitis is associated with preeclampsia in pregnant women', Journal of periodontology, vol. 77, no. 2, pp. 182-188. https://doi.org/10.1902/jop.2006.050020
Contreras, Adolfo ; Herrera, J. A. ; Soto, J. E. ; Arce Munoz, Roger Mauricio ; Jaramillo, A. ; Botero, J. E. / Periodontitis is associated with preeclampsia in pregnant women. In: Journal of periodontology. 2006 ; Vol. 77, No. 2. pp. 182-188.
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abstract = "Background: Recent investigations have demonstrated a itive association between periodontitis and pregnancy complications. The purpose of this study was to determine the effect of periodontitis and the subgingival microbial composition on preeclampsia. Methods: A case-control study was carried out in Cali, Colombia that included 130 preeclamptic and 243 non-preeclamptic women between 26 to 36 weeks of pregnancy. Sociodemographic data, obstetric risk factors, periodontal status, and subgingival microbial composition were determined in both groups. Preeclampsia was defined as blood pressure ≥140/90 mm Hg, and ≥2+ proteinuria, confirmed by 0.3 g proteinuria/24 hours of urine specimens. Controls were healthy pregnant women. Odds ratios (ORs) for periodontitis and subgingival microbiota compositions were calculated. Results: A total of 83 out of 130 preeclamptic women (63.8{\%}) and 89 out of 243 controls (36.6{\%}) had chronic periodontitis (OR: 3.0; 95{\%} confidence interval (CI): 1.91 to 4.87; P<0.001). Clinical attachment loss increased in the case group (4.0 ± 0.10 mm) compared to the control group (3.0 ± 0.08 mm) (P <0.001). The average newborn birth weight from preeclamptic mothers was 2.453 g, whereas in controls was 2.981 g (P<0.001). Two red complex microorganisms, Porphyromonas gingivalis and Tannerella forsythensis, and the green complex microorganism Eikenella corrodens were more prevalent in the preeclamptic group than in controls (P <0.01). Conclusions: Chronic periodontal disease and the presence of P. gingivalis, T. forsythensis, and E. corrodens were significantly associated with preeclampsia in pregnant women. Further research is needed to establish pathogenic mechanisms of active periodontal disease and subgingival periodontopathogens related to preeclampsia development.",
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