Peripheral administration of human corticotropin-releasing hormone

A novel method to increase energy expenditure and fat oxidation in man

Steven R. Smith, L. De Jonge, M. Pellymounter, T. Nguyen, Ruth Babette Harris, D. York, S. Redmann, J. Rood, G. A. Bray

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

CRH increases energy expenditure and decreases food intake in experimental animals. We proposed the hypothesis that peripheral administration of CRH might increase energy expenditure in human subjects. Four men and four women (age, 19-39 yr) were randomized to a double blind, cross-over trial to test the effect of human CRH (hCRH), ovine CRH (oCRH), and placebo on resting energy expenditure measured by indirect calorimetry. CRH was administered by primed continuous infusion at progressively increasing doses of 0.5, 1.0, and 2.0 μg/kg-h at 2-h intervals. hCRH increased resting energy expenditure by 13.9% at the end of the infusion. Respiratory quotient fell from 0.828 to 0.768 during the hCRH infusion compared with a fall from 0.836 to 0.807 during placebo infusion (P < 0.05). Fat oxidation increased by 55% compared with placebo at the highest dose of hCRH. Heart rate increased during hCRH to 10.7 bpm higher than placebo (P < 0.05). oCRH did not increase heart rate. oCRH also had no significant effect on respiratory quotient, and only a small effect on energy expenditure. During hCRH infusion, venous plasma epinephrine, norepinephrine, glycerol, and nonesterified fatty acid levels were not significantly different from those during placebo treatment. Peripheral CRH administration offers a novel strategy to increase energy expenditure.

Original languageEnglish (US)
Pages (from-to)1991-1998
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number5
DOIs
StatePublished - Jun 5 2001
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Energy Metabolism
Fats
Oxidation
Placebos
Sheep
Heart Rate
Indirect Calorimetry
Calorimetry
Nonesterified Fatty Acids
Glycerol
Epinephrine
Norepinephrine
Animals
Cross-Over Studies
Plasmas
Eating

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Peripheral administration of human corticotropin-releasing hormone : A novel method to increase energy expenditure and fat oxidation in man. / Smith, Steven R.; De Jonge, L.; Pellymounter, M.; Nguyen, T.; Harris, Ruth Babette; York, D.; Redmann, S.; Rood, J.; Bray, G. A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 5, 05.06.2001, p. 1991-1998.

Research output: Contribution to journalArticle

Smith, Steven R. ; De Jonge, L. ; Pellymounter, M. ; Nguyen, T. ; Harris, Ruth Babette ; York, D. ; Redmann, S. ; Rood, J. ; Bray, G. A. / Peripheral administration of human corticotropin-releasing hormone : A novel method to increase energy expenditure and fat oxidation in man. In: Journal of Clinical Endocrinology and Metabolism. 2001 ; Vol. 86, No. 5. pp. 1991-1998.
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