Abstract
Antiviral cytotoxic memory CD8+ T cells adoptively transferred to mice which are persistently infected with lymphocytic choriomeningitis virus WE or DOCILE initially proliferated extensively; they either caused the death of the recipient or, alternatively, disappeared within a few days. Apparently, the complete and coordinated induction and stimulation by widely distributed viral antigen caused these memory T cells to die before virus had been eliminated from the host. Thus memory T cells are as susceptible to peripheral exhaustion/deletion as unprimed T cells. These results indicate possible limitations of exclusively CD8+ T cell‐mediated adoptive immunotherapy against viral infections or tumors.
Original language | English (US) |
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Pages (from-to) | 3306-3311 |
Number of pages | 6 |
Journal | European Journal of Immunology |
Volume | 23 |
Issue number | 12 |
DOIs | |
State | Published - Dec 1993 |
Externally published | Yes |
Keywords
- Peripheral deletion
- T cell memory
- Virus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology