Peripheral clonal deletion of antiviral memory CD8+ T cells

Demetrius Moskophidis, Elisabeth Laine, Rolf M. Zinkernagel

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Antiviral cytotoxic memory CD8+ T cells adoptively transferred to mice which are persistently infected with lymphocytic choriomeningitis virus WE or DOCILE initially proliferated extensively; they either caused the death of the recipient or, alternatively, disappeared within a few days. Apparently, the complete and coordinated induction and stimulation by widely distributed viral antigen caused these memory T cells to die before virus had been eliminated from the host. Thus memory T cells are as susceptible to peripheral exhaustion/deletion as unprimed T cells. These results indicate possible limitations of exclusively CD8+ T cell‐mediated adoptive immunotherapy against viral infections or tumors.

Original languageEnglish (US)
Pages (from-to)3306-3311
Number of pages6
JournalEuropean Journal of Immunology
Volume23
Issue number12
DOIs
StatePublished - Dec 1993

Keywords

  • Peripheral deletion
  • T cell memory
  • Virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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