Peripheral clonal deletion of antiviral memory CD8+ T cells

Demetrius Moskophidis, Elisabeth Laine, Rolf M. Zinkernagel

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Antiviral cytotoxic memory CD8+ T cells adoptively transferred to mice which are persistently infected with lymphocytic choriomeningitis virus WE or DOCILE initially proliferated extensively; they either caused the death of the recipient or, alternatively, disappeared within a few days. Apparently, the complete and coordinated induction and stimulation by widely distributed viral antigen caused these memory T cells to die before virus had been eliminated from the host. Thus memory T cells are as susceptible to peripheral exhaustion/deletion as unprimed T cells. These results indicate possible limitations of exclusively CD8+ T cell‐mediated adoptive immunotherapy against viral infections or tumors.

Original languageEnglish (US)
Pages (from-to)3306-3311
Number of pages6
JournalEuropean Journal of Immunology
Volume23
Issue number12
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Clonal Deletion
Antiviral Agents
T-Lymphocytes
Lymphocytic choriomeningitis virus
Adoptive Immunotherapy
Viral Antigens
Virus Diseases
Viruses
Neoplasms

Keywords

  • Peripheral deletion
  • T cell memory
  • Virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Peripheral clonal deletion of antiviral memory CD8+ T cells. / Moskophidis, Demetrius; Laine, Elisabeth; Zinkernagel, Rolf M.

In: European Journal of Immunology, Vol. 23, No. 12, 01.01.1993, p. 3306-3311.

Research output: Contribution to journalArticle

Moskophidis, Demetrius ; Laine, Elisabeth ; Zinkernagel, Rolf M. / Peripheral clonal deletion of antiviral memory CD8+ T cells. In: European Journal of Immunology. 1993 ; Vol. 23, No. 12. pp. 3306-3311.
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