Periventricular closure of ventricular septal defects without cardiopulmonary bypass

Zahid Amin, Xiaoping Gu, James M. Berry, Jack L. Titus, Samuel S. Gidding, Albert P. Rocchini

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Background. Minimally invasive techniques are currently in use to close atrial and ventricular septal defects (VSD). Cardiopulmonary bypass (CPB) is instituted via the femoral vessels, which may cause injury to these vessels, especially in younger patients. The objectives of this study were to demonstrate the feasibility of periventricular closure of muscular VSD (MVSD) and paramembranous VSD (PVSD) without CPB, using the Amplatz VSD device.Methods. Five Yucatan pigs with naturally occurring PVSD (3- to 7-mm diameter) and 5 dogs with surgically created MVSD (6- to 14-mm diameter) were subjects of this study. The VSDs were closed intraoperatively with a 7-French delivery sheath inserted through the free wall of the right (n = 5) or left ventricle (n = 5), under epicardial echocardiogram guidance. The animals were followed for 3 months.Results. There was no operative mortality. All MVSD closed after placement of the device. Closure rate of PVSD was 4 of 5 after placement and 3 of 5 after 3 months. One pig developed aortic incompetence at the last follow-up.Conclusions. Perventricular closure of MVSD and PVSD is feasible. Avoidance of CPB can decrease recovery time, its complications, and trauma to the femoral vessels. Copyright (C) 1999 The Society of Thoracic Surgeons.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalAnnals of Thoracic Surgery
Volume68
Issue number1
DOIs
StatePublished - Jul 1 1999

Fingerprint

Ventricular Heart Septal Defects
Cardiopulmonary Bypass
Thigh
Swine
Equipment and Supplies
Aortic Valve Insufficiency
Atrial Heart Septal Defects
Wounds and Injuries
Heart Ventricles
Dogs
Mortality

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Periventricular closure of ventricular septal defects without cardiopulmonary bypass. / Amin, Zahid; Gu, Xiaoping; Berry, James M.; Titus, Jack L.; Gidding, Samuel S.; Rocchini, Albert P.

In: Annals of Thoracic Surgery, Vol. 68, No. 1, 01.07.1999, p. 149-153.

Research output: Contribution to journalArticle

Amin, Zahid ; Gu, Xiaoping ; Berry, James M. ; Titus, Jack L. ; Gidding, Samuel S. ; Rocchini, Albert P. / Periventricular closure of ventricular septal defects without cardiopulmonary bypass. In: Annals of Thoracic Surgery. 1999 ; Vol. 68, No. 1. pp. 149-153.
@article{5b2e90980b9f454bbee2907b2f22603c,
title = "Periventricular closure of ventricular septal defects without cardiopulmonary bypass",
abstract = "Background. Minimally invasive techniques are currently in use to close atrial and ventricular septal defects (VSD). Cardiopulmonary bypass (CPB) is instituted via the femoral vessels, which may cause injury to these vessels, especially in younger patients. The objectives of this study were to demonstrate the feasibility of periventricular closure of muscular VSD (MVSD) and paramembranous VSD (PVSD) without CPB, using the Amplatz VSD device.Methods. Five Yucatan pigs with naturally occurring PVSD (3- to 7-mm diameter) and 5 dogs with surgically created MVSD (6- to 14-mm diameter) were subjects of this study. The VSDs were closed intraoperatively with a 7-French delivery sheath inserted through the free wall of the right (n = 5) or left ventricle (n = 5), under epicardial echocardiogram guidance. The animals were followed for 3 months.Results. There was no operative mortality. All MVSD closed after placement of the device. Closure rate of PVSD was 4 of 5 after placement and 3 of 5 after 3 months. One pig developed aortic incompetence at the last follow-up.Conclusions. Perventricular closure of MVSD and PVSD is feasible. Avoidance of CPB can decrease recovery time, its complications, and trauma to the femoral vessels. Copyright (C) 1999 The Society of Thoracic Surgeons.",
author = "Zahid Amin and Xiaoping Gu and Berry, {James M.} and Titus, {Jack L.} and Gidding, {Samuel S.} and Rocchini, {Albert P.}",
year = "1999",
month = "7",
day = "1",
doi = "10.1016/S0003-4975(99)00519-6",
language = "English (US)",
volume = "68",
pages = "149--153",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Periventricular closure of ventricular septal defects without cardiopulmonary bypass

AU - Amin, Zahid

AU - Gu, Xiaoping

AU - Berry, James M.

AU - Titus, Jack L.

AU - Gidding, Samuel S.

AU - Rocchini, Albert P.

PY - 1999/7/1

Y1 - 1999/7/1

N2 - Background. Minimally invasive techniques are currently in use to close atrial and ventricular septal defects (VSD). Cardiopulmonary bypass (CPB) is instituted via the femoral vessels, which may cause injury to these vessels, especially in younger patients. The objectives of this study were to demonstrate the feasibility of periventricular closure of muscular VSD (MVSD) and paramembranous VSD (PVSD) without CPB, using the Amplatz VSD device.Methods. Five Yucatan pigs with naturally occurring PVSD (3- to 7-mm diameter) and 5 dogs with surgically created MVSD (6- to 14-mm diameter) were subjects of this study. The VSDs were closed intraoperatively with a 7-French delivery sheath inserted through the free wall of the right (n = 5) or left ventricle (n = 5), under epicardial echocardiogram guidance. The animals were followed for 3 months.Results. There was no operative mortality. All MVSD closed after placement of the device. Closure rate of PVSD was 4 of 5 after placement and 3 of 5 after 3 months. One pig developed aortic incompetence at the last follow-up.Conclusions. Perventricular closure of MVSD and PVSD is feasible. Avoidance of CPB can decrease recovery time, its complications, and trauma to the femoral vessels. Copyright (C) 1999 The Society of Thoracic Surgeons.

AB - Background. Minimally invasive techniques are currently in use to close atrial and ventricular septal defects (VSD). Cardiopulmonary bypass (CPB) is instituted via the femoral vessels, which may cause injury to these vessels, especially in younger patients. The objectives of this study were to demonstrate the feasibility of periventricular closure of muscular VSD (MVSD) and paramembranous VSD (PVSD) without CPB, using the Amplatz VSD device.Methods. Five Yucatan pigs with naturally occurring PVSD (3- to 7-mm diameter) and 5 dogs with surgically created MVSD (6- to 14-mm diameter) were subjects of this study. The VSDs were closed intraoperatively with a 7-French delivery sheath inserted through the free wall of the right (n = 5) or left ventricle (n = 5), under epicardial echocardiogram guidance. The animals were followed for 3 months.Results. There was no operative mortality. All MVSD closed after placement of the device. Closure rate of PVSD was 4 of 5 after placement and 3 of 5 after 3 months. One pig developed aortic incompetence at the last follow-up.Conclusions. Perventricular closure of MVSD and PVSD is feasible. Avoidance of CPB can decrease recovery time, its complications, and trauma to the femoral vessels. Copyright (C) 1999 The Society of Thoracic Surgeons.

UR - http://www.scopus.com/inward/record.url?scp=0032786977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032786977&partnerID=8YFLogxK

U2 - 10.1016/S0003-4975(99)00519-6

DO - 10.1016/S0003-4975(99)00519-6

M3 - Article

C2 - 10421131

AN - SCOPUS:0032786977

VL - 68

SP - 149

EP - 153

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 1

ER -