Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission

Susanna L. Lamers, John W. Sleasman, Jin Xiong She, Kimberly A. Barrie, Steven M. Pomeroy, Douglas J. Barrett, Maureen M. Goodenow

Research output: Contribution to journalArticle

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Abstract

The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env V1 and V2 sequences in longitudinal samples from two HIV-1- infected mothers, each with three children infected by maternal transmission of the virus. Sequences in samples that were obtained from two infants at 2 d and 4 wk after birth displayed more variation in V1 and V2 than maternal samples obtained at the same times. Multiple HIV-1 genotypes were identified in each mother. In each family, multiple maternal HIV-1 genotypes were transmitted to the infants. Specific amino acid residues in the hypervariable domains were conserved within sequences from each family producing a family- specific amino acid signature pattern in V1 and V2. Viruses that were highly related to maternal viruses in signature pattern persisted for as long as 4 yr in the older children. Results support a model of transmission involving multiple HIV-1 genotypes with development of genetic variation from differential outgrowth and accumulation of genetic changes within each individual.

Original languageEnglish (US)
Pages (from-to)380-390
Number of pages11
JournalJournal of Clinical Investigation
Volume93
Issue number1
DOIs
StatePublished - Jan 1994

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Genotype
Mothers
HIV-1
HIV
Viruses
Amino Acids
Conserved Sequence
Nucleotides
Parturition

Keywords

  • human immunodeficiency virus I genetic variation
  • maternal transmission

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission. / Lamers, Susanna L.; Sleasman, John W.; She, Jin Xiong; Barrie, Kimberly A.; Pomeroy, Steven M.; Barrett, Douglas J.; Goodenow, Maureen M.

In: Journal of Clinical Investigation, Vol. 93, No. 1, 01.1994, p. 380-390.

Research output: Contribution to journalArticle

Lamers, Susanna L. ; Sleasman, John W. ; She, Jin Xiong ; Barrie, Kimberly A. ; Pomeroy, Steven M. ; Barrett, Douglas J. ; Goodenow, Maureen M. / Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission. In: Journal of Clinical Investigation. 1994 ; Vol. 93, No. 1. pp. 380-390.
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