Persistent infection with neurotropic herpes viruses and cognitive impairment

A. M.M. Watson, K. M. Prasad, L. Klei, J. A. Wood, R. H. Yolken, R. C. Gur, L. D. Bradford, M. E. Calkins, J. Richard, N. Edwards, R. M. Savage, T. B. Allen, J. Kwentus, Joseph Patrick McEvoy, Alberto Santos, H. W. Wiener, R. C.P. Go, R. T. Perry, H. A. Nasrallah, R. E. Gur & 2 others B. Devlin, V. L. Nimgaonkar

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background Herpes virus infections can cause cognitive impairment during and after acute encephalitis. Although chronic, latent/persistent infection is considered to be relatively benign, some studies have documented cognitive impairment in exposed persons that is untraceable to encephalitis. These studies were conducted among schizophrenia (SZ) patients or older community dwellers, among whom it is difficult to control for the effects of co-morbid illness and medications. To determine whether the associations can be generalized to other groups, we examined a large sample of younger control individuals, SZ patients and their non-psychotic relatives (n=1852). Method Using multivariate models, cognitive performance was evaluated in relation to exposures to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV), controlling for familial and diagnostic status and sociodemographic variables, including occupation and educational status. Composite cognitive measures were derived from nine cognitive domains using principal components of heritability (PCH). Exposure was indexed by antibodies to viral antigens. Results PCH1, the most heritable component of cognitive performance, declines with exposure to CMV or HSV-1 regardless of case/relative/control group status (p = 1.09 × 10-5 and 0.01 respectively), with stronger association with exposure to multiple herpes viruses (β =-0.25, p = 7.28 × 10-10). There were no significant interactions between exposure and group status. Conclusions Latent/persistent herpes virus infections can be associated with cognitive impairments regardless of other health status.

Original languageEnglish (US)
Pages (from-to)1023-1031
Number of pages9
JournalPsychological Medicine
Volume43
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Viruses
Human Herpesvirus 1
Virus Diseases
Encephalitis
Infection
Cytomegalovirus
Schizophrenia
Educational Status
Human Herpesvirus 2
Viral Antigens
Occupations
Health Status
Control Groups
Cognitive Dysfunction
Antibodies

Keywords

  • Cognition
  • HSV-1
  • HSV-2
  • cytomegalovirus
  • schizophrenia

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Watson, A. M. M., Prasad, K. M., Klei, L., Wood, J. A., Yolken, R. H., Gur, R. C., ... Nimgaonkar, V. L. (2013). Persistent infection with neurotropic herpes viruses and cognitive impairment. Psychological Medicine, 43(5), 1023-1031. https://doi.org/10.1017/S003329171200195X

Persistent infection with neurotropic herpes viruses and cognitive impairment. / Watson, A. M.M.; Prasad, K. M.; Klei, L.; Wood, J. A.; Yolken, R. H.; Gur, R. C.; Bradford, L. D.; Calkins, M. E.; Richard, J.; Edwards, N.; Savage, R. M.; Allen, T. B.; Kwentus, J.; McEvoy, Joseph Patrick; Santos, Alberto; Wiener, H. W.; Go, R. C.P.; Perry, R. T.; Nasrallah, H. A.; Gur, R. E.; Devlin, B.; Nimgaonkar, V. L.

In: Psychological Medicine, Vol. 43, No. 5, 01.05.2013, p. 1023-1031.

Research output: Contribution to journalArticle

Watson, AMM, Prasad, KM, Klei, L, Wood, JA, Yolken, RH, Gur, RC, Bradford, LD, Calkins, ME, Richard, J, Edwards, N, Savage, RM, Allen, TB, Kwentus, J, McEvoy, JP, Santos, A, Wiener, HW, Go, RCP, Perry, RT, Nasrallah, HA, Gur, RE, Devlin, B & Nimgaonkar, VL 2013, 'Persistent infection with neurotropic herpes viruses and cognitive impairment', Psychological Medicine, vol. 43, no. 5, pp. 1023-1031. https://doi.org/10.1017/S003329171200195X
Watson AMM, Prasad KM, Klei L, Wood JA, Yolken RH, Gur RC et al. Persistent infection with neurotropic herpes viruses and cognitive impairment. Psychological Medicine. 2013 May 1;43(5):1023-1031. https://doi.org/10.1017/S003329171200195X
Watson, A. M.M. ; Prasad, K. M. ; Klei, L. ; Wood, J. A. ; Yolken, R. H. ; Gur, R. C. ; Bradford, L. D. ; Calkins, M. E. ; Richard, J. ; Edwards, N. ; Savage, R. M. ; Allen, T. B. ; Kwentus, J. ; McEvoy, Joseph Patrick ; Santos, Alberto ; Wiener, H. W. ; Go, R. C.P. ; Perry, R. T. ; Nasrallah, H. A. ; Gur, R. E. ; Devlin, B. ; Nimgaonkar, V. L. / Persistent infection with neurotropic herpes viruses and cognitive impairment. In: Psychological Medicine. 2013 ; Vol. 43, No. 5. pp. 1023-1031.
@article{5787deb2f7fd42f9a27bc9b5987c0e1d,
title = "Persistent infection with neurotropic herpes viruses and cognitive impairment",
abstract = "Background Herpes virus infections can cause cognitive impairment during and after acute encephalitis. Although chronic, latent/persistent infection is considered to be relatively benign, some studies have documented cognitive impairment in exposed persons that is untraceable to encephalitis. These studies were conducted among schizophrenia (SZ) patients or older community dwellers, among whom it is difficult to control for the effects of co-morbid illness and medications. To determine whether the associations can be generalized to other groups, we examined a large sample of younger control individuals, SZ patients and their non-psychotic relatives (n=1852). Method Using multivariate models, cognitive performance was evaluated in relation to exposures to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV), controlling for familial and diagnostic status and sociodemographic variables, including occupation and educational status. Composite cognitive measures were derived from nine cognitive domains using principal components of heritability (PCH). Exposure was indexed by antibodies to viral antigens. Results PCH1, the most heritable component of cognitive performance, declines with exposure to CMV or HSV-1 regardless of case/relative/control group status (p = 1.09 × 10-5 and 0.01 respectively), with stronger association with exposure to multiple herpes viruses (β =-0.25, p = 7.28 × 10-10). There were no significant interactions between exposure and group status. Conclusions Latent/persistent herpes virus infections can be associated with cognitive impairments regardless of other health status.",
keywords = "Cognition, HSV-1, HSV-2, cytomegalovirus, schizophrenia",
author = "Watson, {A. M.M.} and Prasad, {K. M.} and L. Klei and Wood, {J. A.} and Yolken, {R. H.} and Gur, {R. C.} and Bradford, {L. D.} and Calkins, {M. E.} and J. Richard and N. Edwards and Savage, {R. M.} and Allen, {T. B.} and J. Kwentus and McEvoy, {Joseph Patrick} and Alberto Santos and Wiener, {H. W.} and Go, {R. C.P.} and Perry, {R. T.} and Nasrallah, {H. A.} and Gur, {R. E.} and B. Devlin and Nimgaonkar, {V. L.}",
year = "2013",
month = "5",
day = "1",
doi = "10.1017/S003329171200195X",
language = "English (US)",
volume = "43",
pages = "1023--1031",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "5",

}

TY - JOUR

T1 - Persistent infection with neurotropic herpes viruses and cognitive impairment

AU - Watson, A. M.M.

AU - Prasad, K. M.

AU - Klei, L.

AU - Wood, J. A.

AU - Yolken, R. H.

AU - Gur, R. C.

AU - Bradford, L. D.

AU - Calkins, M. E.

AU - Richard, J.

AU - Edwards, N.

AU - Savage, R. M.

AU - Allen, T. B.

AU - Kwentus, J.

AU - McEvoy, Joseph Patrick

AU - Santos, Alberto

AU - Wiener, H. W.

AU - Go, R. C.P.

AU - Perry, R. T.

AU - Nasrallah, H. A.

AU - Gur, R. E.

AU - Devlin, B.

AU - Nimgaonkar, V. L.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Background Herpes virus infections can cause cognitive impairment during and after acute encephalitis. Although chronic, latent/persistent infection is considered to be relatively benign, some studies have documented cognitive impairment in exposed persons that is untraceable to encephalitis. These studies were conducted among schizophrenia (SZ) patients or older community dwellers, among whom it is difficult to control for the effects of co-morbid illness and medications. To determine whether the associations can be generalized to other groups, we examined a large sample of younger control individuals, SZ patients and their non-psychotic relatives (n=1852). Method Using multivariate models, cognitive performance was evaluated in relation to exposures to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV), controlling for familial and diagnostic status and sociodemographic variables, including occupation and educational status. Composite cognitive measures were derived from nine cognitive domains using principal components of heritability (PCH). Exposure was indexed by antibodies to viral antigens. Results PCH1, the most heritable component of cognitive performance, declines with exposure to CMV or HSV-1 regardless of case/relative/control group status (p = 1.09 × 10-5 and 0.01 respectively), with stronger association with exposure to multiple herpes viruses (β =-0.25, p = 7.28 × 10-10). There were no significant interactions between exposure and group status. Conclusions Latent/persistent herpes virus infections can be associated with cognitive impairments regardless of other health status.

AB - Background Herpes virus infections can cause cognitive impairment during and after acute encephalitis. Although chronic, latent/persistent infection is considered to be relatively benign, some studies have documented cognitive impairment in exposed persons that is untraceable to encephalitis. These studies were conducted among schizophrenia (SZ) patients or older community dwellers, among whom it is difficult to control for the effects of co-morbid illness and medications. To determine whether the associations can be generalized to other groups, we examined a large sample of younger control individuals, SZ patients and their non-psychotic relatives (n=1852). Method Using multivariate models, cognitive performance was evaluated in relation to exposures to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and cytomegalovirus (CMV), controlling for familial and diagnostic status and sociodemographic variables, including occupation and educational status. Composite cognitive measures were derived from nine cognitive domains using principal components of heritability (PCH). Exposure was indexed by antibodies to viral antigens. Results PCH1, the most heritable component of cognitive performance, declines with exposure to CMV or HSV-1 regardless of case/relative/control group status (p = 1.09 × 10-5 and 0.01 respectively), with stronger association with exposure to multiple herpes viruses (β =-0.25, p = 7.28 × 10-10). There were no significant interactions between exposure and group status. Conclusions Latent/persistent herpes virus infections can be associated with cognitive impairments regardless of other health status.

KW - Cognition

KW - HSV-1

KW - HSV-2

KW - cytomegalovirus

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84875950697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875950697&partnerID=8YFLogxK

U2 - 10.1017/S003329171200195X

DO - 10.1017/S003329171200195X

M3 - Article

VL - 43

SP - 1023

EP - 1031

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 5

ER -