Personal digital assistants used to document compliance of bacterial vaginosis treatment

Jennifer B. Bartley, Daron Gale Ferris, Lynn M. Allmond, Eileen D. Dickman, James K. Dias, Jerry Lambert

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Objective: The objective of this study was to estimate patient compliance with oral and vaginal metronidazole treatment of bacterial vaginosis using personal digital assistants (PDAs) and paper diaries. Goal: The goal of this study was to assess a novel compliance documentation approach. Study: After each dose of intravaginal or oral metronidazole, 71 subjects recorded the time on a paper diary and answered questions on a PDA. All PDA entries were unknowingly time-date-stamped. Subjects returned for 2- and 6-week posttreatment examinations. Compliance was calculated using a repeated-measures multivariate analysis of variance (ANOVA). Results: Mean patient compliance rates within the oral metronidazole group were greater with the paper diary compared with the PDA (68.3% and 50.0%, respectively, P = 0.001). The observed rate of compliance agreement for PDA versus paper diary was 69.0% (kappa = 0.4). The majority of noncompliant subjects reported they were compliant with the PDA and paper diary. Conclusions: PDAs could more accurately document true compliance rates and could be reasonable instruments to assess compliance in intravaginal antimicrobial drug or contraceptive trials.

Original languageEnglish (US)
Pages (from-to)488-491
Number of pages4
JournalSexually Transmitted Diseases
Issue number8
StatePublished - Aug 1 2004

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases


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