Peyer's patches: Organized lymphoid structures for the induction of mucosal immune responses in the intestine

L. H.C. Makala, N. Suzuki, H. Nagasawa

Research output: Contribution to journalReview article

39 Scopus citations


Peyer's patches (PP) comprise transmucosal clusters of lymphoid follicles overlaid with a specialized lympho-epithelium and consequently play a central role in the induction of mucosal immune responses in the gut. Despite considerable achievements in the last 3 decades, in our understanding of how PP are involved in the induction of immune responses, much remains to be learned about these major organized lymphoid organs. The history and current status of PP termed 'the major inductive site of immune responses' is reviewed. The present understanding of PP biology and function, taking into account their preferential and unique retention of immune competent cells at specific sites, is discussed.

Original languageEnglish (US)
Pages (from-to)55-68
Number of pages14
Issue number2
Publication statusPublished - Dec 1 2002



  • Distribution
  • IgA
  • Immune response
  • Ontogeny
  • Structure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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