Abstract
Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Publisher | Springer New York LLC |
| Pages | 243-258 |
| Number of pages | 16 |
| DOIs | |
| State | Published - Jan 1 2019 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 1134 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
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Keywords
- Biologic roles
- Cancer
- Diagnostic marker
- Drug target
- Gene regulations
- PFKP
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
PFKP signaling at a glance : An emerging mediator of cancer cell metabolism. / Lang, Liwei; Chemmalakuzhy, Ron; Shay, Chloe; Teng, Yong.
Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 243-258 (Advances in Experimental Medicine and Biology; Vol. 1134).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - PFKP signaling at a glance
T2 - An emerging mediator of cancer cell metabolism
AU - Lang, Liwei
AU - Chemmalakuzhy, Ron
AU - Shay, Chloe
AU - Teng, Yong
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.
AB - Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.
KW - Biologic roles
KW - Cancer
KW - Diagnostic marker
KW - Drug target
KW - Gene regulations
KW - PFKP
UR - http://www.scopus.com/inward/record.url?scp=85063966138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063966138&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-12668-1_13
DO - 10.1007/978-3-030-12668-1_13
M3 - Chapter
C2 - 30919341
AN - SCOPUS:85063966138
T3 - Advances in Experimental Medicine and Biology
SP - 243
EP - 258
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -