PFKP signaling at a glance: An emerging mediator of cancer cell metabolism

Liwei Lang, Ron Chemmalakuzhy, Chloe Shay, Yong Teng

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Phosphofructokinase-1 (PFK-1), a rate-determining enzyme of glycolysis, is an allosteric enzyme that regulates the oxidation of glucose in cellular respiration. Glycolysis phosphofructokinase platelet (PFKP) is the platelet isoform and works as an important mediator of cell metabolism. Considering that PFKP is a crucial player in many steps of cancer initiation and metastasis, we reviewed the specificities and complexities of PFKP and its biological roles in human diseases, especially malignant tumors. The possible use of PFKP as a diagnostic marker or a drug target in the prevention or treatment of cancer is also discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages243-258
Number of pages16
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1134
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Biologic roles
  • Cancer
  • Diagnostic marker
  • Drug target
  • Gene regulations
  • PFKP

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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